Publication Name	World Journal of Radiology
Manuscript ID	19926
Country	India

Received	2015-05-26 09:32
Peer-Review Started	2015-05-27 20:19
First Decision by Editorial Office Director
Return for Revision	2015-06-25 15:08
Revised	2015-07-03 13:09
Publication Fee Transferred
Second Decision by Editor	2015-07-24 11:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2015-08-03 15:53
Articles in Press	2015-08-03 15:53
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-09-23 19:55
Publish the Manuscript Online	2015-10-13 17:27

ISSN	1949-8470 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Minireviews
Article Title	Radiation signature on exposed cells: Relevance in dose estimation
Manuscript Source	Invited Manuscript
All Author List	Venkatachalam Perumal, Tamizh Selvan Gnana Sekaran, Venkateswarlu Raavi, Safa Abdul Syed Basheerudeen, Karthik Kanagaraj, Amith Roy Chowdhury and Solomon FD Paul
Funding Agency and Grant Number	Funding Agency Grant Number Department of Science and Technology, Government of India SR-SO/HS-127/2012 Defence Research and Development Organisation, Government of India DLS/81/48222/LSRB-261 Atomic Energy Regulatory Board, Government of India 58/04/2014
Corresponding Author	Venkatachalam Perumal, PhD, Professor, Department of Human Genetics, College of Biomedical Sciences, Technology and Research, Sri Ramachandra University, No.1, Ramachandra Nagar Porur, Chennai 600 116, India. venkip@yahoo.com
Key Words	Biomarker; Dicentric chromosomes; Micro­nucleus; Fluorescence in-situ hybridization
Core Tip	Of the well-established biomarker, the dicentric chromosome assay remains a gold standard, with sensitivity and specificity to radiation. In contrast, micronucleus is simple, rapid and potential for triage, though the sensitivity is less and not able to differen-tiate the partial body exposure from that of whole body exposure. The expensive fluorescence in-situ hybridization has the advantage that it can be employed in chronic and retrospective dose estimation. The γ-H2AX assay has a potential for triage despite the fact of limited stability. To conclude none of the assay could fulfil all the criteria of an ideal biomarker.
Publish Date	2015-10-13 17:27
Citation	Perumal V, Gnana Sekaran TS, Raavi V, Basheerudeen SAS, Kanagaraj K, Chowdhury AR, Paul SFD. Radiation signature on exposed cells: Relevance in dose estimation. World J Radiol 2015; 7(9): 266-278
URL	http://www.wjgnet.com/1949-8470/full/v7/i9/266.htm
DOI	http://dx.doi.org/10.4329/wjr.v7.i9.266

Full Article (PDF)	WJR-7-266.pdf
Full Article (Word)	WJR-7-266.doc
Manuscript File	19926-Review.docx
Answering Reviewers	19926-Answering reviewers.pdf
Audio Core Tip	19926-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	19926-Conflict-of-interest statement.pdf
Copyright License Agreement	19926-Copyright assignment.pdf
Peer-review Report	19926-Peer-review(s).pdf
Scientific Misconduct Check	19926-Scientific misconduct check.pdf
Scientific Editor Work List	19926-Scientific editor work list.pdf