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Articles Published Processes
12/24/2015 11:11:00 AM | Browse: 1008 | Download: 2029
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Received |
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2015-05-26 09:19 |
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Peer-Review Started |
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2015-05-27 11:54 |
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To Make the First Decision |
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2015-08-26 15:10 |
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Return for Revision |
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2015-10-12 11:24 |
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Revised |
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2015-09-12 22:24 |
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Second Decision |
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2015-10-12 16:32 |
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Accepted by Journal Editor-in-Chief |
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2015-10-12 18:24 |
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Accepted by Executive Editor-in-Chief |
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2015-10-20 09:17 |
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Articles in Press |
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2015-10-20 09:17 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-11-05 04:12 |
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Typeset the Manuscript |
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2015-12-09 11:13 |
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Publish the Manuscript Online |
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2015-12-24 11:11 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Hypoxia-inducible factor-1 modulates upregulation of mutT homolog-1 in colorectal cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yuan Qiu, Hong Zheng, Li-Hua Sun, Ke Peng, Wei-Dong Xiao and Hua Yang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81330013 |
| National Natural Science Foundation of China |
81272078(to Yang H) |
| National Natural Science Foundation of China |
81270451(to Xiao WD) |
| Program for Changjiang Scholars and Innovative Research Team in University of Ministry of Education of China |
13051 (to Yang H) |
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| Corresponding Author |
Hua Yang, MD, PhD, Department of General Surgery, Xinqiao Hospital, Third Military Medical University, Xinqiaozhengjie, Chongqing 400037,
China. hwbyang@qq.com
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| Key Words |
Hypoxia-inducible factor-1α; Colorectal cancer; MutT homolog-1; 8-oxo-dGTP; Hypoxia |
| Core Tip |
Hypoxia is a common characteristic of solid tumors. However, the relationship between hypoxia-inducible factor (HIF)-1α and the human mutT homolog (MTH)-1 had not been clearly investigated. The present study revealed a new mechanism through which HIF-1α upregulates MTH-1 expression in colorectal cancer and provided evidence that hypoxia enhances the expression of MTH-1, likely by modulating HIF-1α protein level. These results emphasize the important role of HIF-1α-induced MTH-1 in tumor progression.
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| Publish Date |
2015-12-24 11:11 |
| Citation |
Qiu Y, Zheng H, Sun LH, Peng K, Xiao WD, Yang H. Hypoxia-inducible factor-1 modulates upregulation of mutT homolog-1 in colorectal cancer. World J Gastroenterol 2015; 21(48): 13447-13456 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i48/13447.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i48.13447 |
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