Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	19941
Country	Greece

Received	2015-05-26 09:00
Peer-Review Started	2015-05-28 14:20
To Make the First Decision	2015-06-18 15:13
Return for Revision	2015-06-25 15:31
Revised	2015-07-10 21:11
Second Decision	2015-08-20 16:22
Accepted by Journal Editor-in-Chief	2015-08-21 13:05
Accepted by Executive Editor-in-Chief	2015-08-31 15:52
Articles in Press	2015-08-31 15:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-10 20:17
Publish the Manuscript Online	2015-10-19 09:39

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Editorial
Article Title	Targeted therapies for pancreatic adenocarcinoma: Where do we stand, how far can we go?
Manuscript Source	Invited Manuscript
All Author List	Dimitra Grapsa, Muhammad Wasif Saif and Konstantinos Syrigos
Funding Agency and Grant Number
Corresponding Author	Konstantinos Syrigos, MD, PhD, Professor, Head, Oncology Unit, 3rd Department of Medicine, “Sotiria” General Hospital, Athens University School of Medicine, Mesogion 152, 11527 Athens, Greece. knsyrigos@usa.net
Key Words	Clinical; Cytotoxic chemotherapy; Pancreatic cancer; Preclinical; Targeted agents
Core Tip	Expansion of our knowledge regarding the Expansion of our knowledge regarding the molecular basis of pancreatic cancer has facilitated the development of a significant number of innovative targeted therapies for this lethal disease. Almost all these agents have, nevertheless, failed to produce statistically significant survival benefits when tested in clinical trial settings; therefore, successful clinical translation of preclinical advancements in pancreatic cancer research has yet to be materialized. Future treatment options might include multi-targeted and individualized molecular therapies, ideally guided by patient-specific genomic data, in combination with conventional cytotoxic or other regimens. molecular basis of pancreatic cancer has facilitated the development of a significant number of innovative targeted therapies for this lethal disease. Almost all these agents have, nevertheless, failed to produce statistically significant survival benefits when tested in clinical trial settings; therefore, successful clinical translation of preclinical advancements in pancreatic cancer research has yet to be materialized. Future treatment options might include multi-targeted and individualized molecular therapies, ideally guided by patient-specific genomic data, in combination with conventional cytotoxic or other regimens.
Publish Date	2015-10-19 09:39
Citation	Grapsa D, Saif MW, Syrigos K. Targeted therapies for pancreatic adenocarcinoma: Where do we stand, how far can we go? World J Gastrointest Oncol 2015; 7(10): 172-177
URL	http://www.wjgnet.com/1948-5204/full/v7/i10/172.htm
DOI	http://dx.doi.org/10.4251/wjgo.v7.i10.172

Full Article (PDF)	WJGO-7-172.pdf
Full Article (Word)	WJGO-7-172.doc
Manuscript File	19941-Review.doc
Answering Reviewers	19941-Answering reviewers.pdf
Audio Core Tip	19941-Audio core tip.wma
Conflict-of-Interest Disclosure Form	19941-Conflict-of-interest-statement.pdf
Copyright License Agreement	19941-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	19941-Language certificate.pdf
Peer-review Report	19941-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	19941-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	19941-Scientific misconduct check.pdf
Scientific Editor Work List	19941-Scientific editor work list.pdf