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12/2/2015 11:42:00 AM | Browse: 848 | Download: 1313
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 19941
Country Greece
Received
2015-05-26 09:00
Peer-Review Started
2015-05-28 14:20
To Make the First Decision
2015-06-18 15:13
Return for Revision
2015-06-25 15:31
Revised
2015-07-10 21:11
Second Decision
2015-08-20 16:22
Accepted by Journal Editor-in-Chief
2015-08-21 13:05
Accepted by Company Editor-in-Chief
2015-08-31 15:52
Articles in Press
2015-08-31 15:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-10-10 20:17
Publish the Manuscript Online
2015-10-19 09:39
ISSN 1948-5204 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Editorial
Article Title Targeted therapies for pancreatic adenocarcinoma: Where do we stand, how far can we go?
Manuscript Source Invited Manuscript
All Author List Dimitra Grapsa, Muhammad Wasif Saif and Konstantinos Syrigos
Funding Agency and Grant Number
Corresponding Author Konstantinos Syrigos, MD, PhD, Professor, Head, Oncology Unit, 3rd Department of Medicine, “Sotiria” General Hospital, Athens University School of Medicine, Mesogion 152, 11527 Athens, Greece. knsyrigos@usa.net
Key Words Clinical; Cytotoxic chemotherapy; Pancreatic cancer; Preclinical; Targeted agents
Core Tip Expansion of our knowledge regarding the Expansion of our knowledge regarding the molecular basis of pancreatic cancer has facilitated the development of a significant number of innovative targeted therapies for this lethal disease. Almost all these agents have, nevertheless, failed to produce statistically significant survival benefits when tested in clinical trial settings; therefore, successful clinical translation of preclinical advancements in pancreatic cancer research has yet to be materialized. Future treatment options might include multi-targeted and individualized molecular therapies, ideally guided by patient-specific genomic data, in combination with conventional cytotoxic or other regimens. molecular basis of pancreatic cancer has facilitated the development of a significant number of innovative targeted therapies for this lethal disease. Almost all these agents have, nevertheless, failed to produce statistically significant survival benefits when tested in clinical trial settings; therefore, successful clinical translation of preclinical advancements in pancreatic cancer research has yet to be materialized. Future treatment options might include multi-targeted and individualized molecular therapies, ideally guided by patient-specific genomic data, in combination with conventional cytotoxic or other regimens.
Publish Date 2015-10-19 09:39
Citation Grapsa D, Saif MW, Syrigos K. Targeted therapies for pancreatic adenocarcinoma: Where do we stand, how far can we go? World J Gastrointest Oncol 2015; 7(10): 172-177
URL http://www.wjgnet.com/1948-5204/full/v7/i10/172.htm
DOI http://dx.doi.org/10.4251/wjgo.v7.i10.172
Full Article (PDF) WJGO-7-172.pdf
Full Article (Word) WJGO-7-172.doc
Manuscript File 19941-Review.doc
Answering Reviewers 19941-Answering reviewers.pdf
Audio Core Tip 19941-Audio core tip.wma
Conflict-of-Interest Disclosure Form 19941-Conflict-of-interest-statement.pdf
Copyright License Agreement 19941-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 19941-Language certificate.pdf
Peer-review Report 19941-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 19941-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 19941-Scientific misconduct check.pdf
Scientific Editor Work List 19941-Scientific editor work list.pdf