Publication Name	World Journal of Psychiatry
Manuscript ID	19946
Country	United States

Received	2015-05-26 08:52
Peer-Review Started	2015-05-28 14:53
To Make the First Decision	2015-06-18 15:13
Return for Revision	2015-06-25 15:54
Revised	2015-07-07 04:50
Second Decision	2015-09-28 14:27
Accepted by Journal Editor-in-Chief	2015-09-28 20:14
Accepted by Executive Editor-in-Chief	2015-10-13 17:11
Articles in Press	2015-10-13 17:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-07 19:20
Publish the Manuscript Online	2015-12-18 19:53

ISSN	2220-3206 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Psychiatry
Manuscript Type	Editorial
Article Title	Conceptualization and treatment of negative symptoms in schizophrenia
Manuscript Source	Invited Manuscript
All Author List	Sonali Sarkar, Kiley Hillner and Dawn I Velligan
Funding Agency and Grant Number	Funding Agency Grant Number Patient-Centered Outcomes Institute (2012- 2015)
Corresponding Author	Dawn I Velligan, PhD, Department of Psychiatry University of Texas Health Science Center San Antonio, Mail Stop 7797, 7703 Floyd Curl Drive, San Antonio, TX 78229, United States. velligand@uthscsa.edu
Key Words	Motivation; Functional outcomes; Negative symptoms; Schizophrenia; Treatment
Core Tip	Negative symptoms of schizophrenia including social withdrawal, diminished affective response, lack of interest, poor social drive, and decreased sense of purpose or goal directed activity predict poor functional outcomes for patients with schizophrenia. Negative symptoms and the resulting loss in productivity are responsible for much of the world-wide personal and economic burden of schizophrenia. We describe current theories of negative symptom development and maintenance and address the data regarding current and emerging treatments. Negative symptoms represent an unmet therapeutic need for large numbers of patients. Academia, clinicians, the pharmaceutical industry, research funders, payers and regulators will need to work together to pursue novel treatments to address this public health issue.
Publish Date	2015-12-18 19:53
Citation	Sarkar S, Hillner K, Velligan DI. Conceptualization and treatment of negative symptoms in schizophrenia. World J Psychiatr 2015; 5(4): 352-361
URL	http://www.wjgnet.com/2220-3206/full/v5/i4/352.htm
DOI	http://dx.doi.org/10.5498/wjp.v5.i4.352

Full Article (PDF)	WJP-5-352.pdf
Full Article (Word)	WJP-5-352.doc
Manuscript File	19946-Review.docx
Answering Reviewers	19946-Answering reviewers.pdf
Audio Core Tip	19946-Audio core tip.MP3
Conflict-of-Interest Disclosure Form	19946-Conflict-of-interest statement.pdf
Copyright License Agreement	19946-Copyright assignment.pdf
Peer-review Report	19946-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	19946-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	19946-Scientific misconduct check.pdf
Scientific Editor Work List	19946-Scientific editor work list.pdf