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Articles Published Processes
10/30/2015 8:30:00 AM | Browse: 1046 | Download: 1836
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Received |
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2015-05-27 10:47 |
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Peer-Review Started |
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2015-05-28 15:31 |
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To Make the First Decision |
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2015-07-03 16:47 |
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Return for Revision |
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2015-07-10 17:19 |
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Revised |
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2015-08-02 03:03 |
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Second Decision |
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2015-08-27 12:07 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-09-08 15:08 |
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Articles in Press |
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2015-09-08 15:08 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-10-21 18:06 |
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Publish the Manuscript Online |
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2015-10-30 08:30 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Review |
| Article Title |
Therapies targeting cancer stem cells: Current trends and future challenges
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Denisa L Dragu, Laura G Necula, Coralia Bleotu, Carmen C Diaconu and Mihaela Chivu-Economescu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| European Social Fund |
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| Romanian Government |
POSDRU/159/1.5/S/137390(to Laura G Necula) |
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| Corresponding Author |
Mihaela Chivu-Economescu, PhD, Cellular and Molecular Department, Stefan S. Nicolau Institute of Virology, Mihai Bravu 285 Ave, 030304 Bucharest,
Romania. mihaela.chivu@gmail.com
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| Key Words |
Cancer stem cells; Targeted therapy; Anticancer drugs; Biomarkers; Signaling pathways; Apoptosis |
| Core Tip |
Cancer stem cells (CSCs) play important roles in tumor formation, metastasis and cancer relapse. In this article, we review the literature on the recent progress in developing anti-cancer stem cell strategies based on improved understanding of CSCs properties and molecular features. These novel therapeutic systems are designed with the aim of eradicating CSCs, by targeting surface specific markers and altering signaling pathways or mechanisms involved in CSCs maintenance and drug resistance, and also to disturb microenvironmental signals that sustain CSCs growth, with specific aim of impede CSCs regeneration and cancer relapse.
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| Publish Date |
2015-10-30 08:30 |
| Citation |
Dragu DL, Necula LG, Bleotu C, Diaconu CC, Chivu-Economescu M. Therapies targeting cancer stem cells: Current trends and future challenges. World J Stem Cells 2015; 7(9): 1185-1201 |
| URL |
http://www.wjgnet.com/1948-0210/full/v7/i9/1185.htm |
| DOI |
http://dx.doi.org/10.4252/wjsc.v7.i9.1185 |
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