Publication Name	World Journal of Gastroenterology
Manuscript ID	19956
Country

Received	2015-05-27 10:43
Peer-Review Started	2015-05-28 16:34
To Make the First Decision	2015-07-14 11:47
Return for Revision	2015-07-24 16:24
Revised	2015-08-11 15:21
Second Decision	2015-10-16 13:11
Accepted by Journal Editor-in-Chief	2015-10-16 16:12
Accepted by Executive Editor-in-Chief	2015-10-26 17:49
Articles in Press	2015-10-26 17:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-31 14:39
Publish the Manuscript Online	2015-11-18 12:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?
Manuscript Source	Invited Manuscript
All Author List	Shikha Satendra Singh, Wei Ney Yap, Frank Arfuso, Shreya Kar, Chao Wang, Wanpei Cai, Arunasalam M Dharmarajan, Gautam Sethi and Alan Prem Kumar
Funding Agency and Grant Number
Corresponding Author	Dr. Alan Prem Kumar, PhD, Cancer Science Institute of Singapore, National University of Singapore, Singapore City 117597, Singapore. csiapk@nus.edu.sg
Key Words	Epidemiology; Gastric cancer; PI3K/Akt/mTOR pathway; Predictive biomarkers; Targeted therapy
Core Tip	Gastric cancer (GC) is the fifth most common cancer in the world with highest incidence rate in Eastern Asia and Latin America. With increase in GC patient relapse and drug resistance, targeted therapy is gaining immense popularity for GC treatment. One of the pathways which has been reported to be dysregulated is phosphoinositide-3-kinase B (PI3K)/Akt signaling pathway. This review focuses on how this pathway is crucial in GC oncogenesis. We also summarize the single or dual PI3K/Akt pathway inhibitors under investigation for GC treatment. Thereby, we discuss the plausible novel biomarkers under investigation for a more tailored approach for GC treatment.
Publish Date	2015-11-18 12:39
Citation	Singh SS, Yap WN, Arfuso F, Kar S, Wang C, Cai W, Dharmarajan AM, Sethi G, Kumar AP. Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine? World J Gastroenterol 2015; 21(43): 12261-12273
URL	http://www.wjgnet.com/1007-9327/full/v21/i43/12261.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i43.12261

Full Article (PDF)	WJG-21-12261.pdf
Full Article (Word)	WJG-21-12261.doc
Manuscript File	19956-Review.doc
Answering Reviewers	19956-Answering reviewers.pdf
Audio Core Tip	19956-Audio core tip.mp3
Copyright License Agreement	19956-Copyright assignment.pdf
Peer-review Report	19956-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	19956-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	19956-Scientific misconduct check.pdf
Scientific Editor Work List	19956-Scientific editor work list.pdf