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11/24/2015 3:55:00 PM | Browse: 824 | Download: 638
Publication Name World Journal of Gastroenterology
Manuscript ID 19956
Country/Territory
Received
2015-05-27 10:43
Peer-Review Started
2015-05-28 16:34
To Make the First Decision
2015-07-14 11:47
Return for Revision
2015-07-24 16:24
Revised
2015-08-11 15:21
Second Decision
2015-10-16 13:11
Accepted by Journal Editor-in-Chief
2015-10-16 16:12
Accepted by Company Editor-in-Chief
2015-10-26 17:49
Articles in Press
2015-10-26 17:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-10-31 14:39
Publish the Manuscript Online
2015-11-18 12:39
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Topic Highlights
Article Title Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?
Manuscript Source Invited Manuscript
All Author List Shikha Satendra Singh, Wei Ney Yap, Frank Arfuso, Shreya Kar, Chao Wang, Wanpei Cai, Arunasalam M Dharmarajan, Gautam Sethi and Alan Prem Kumar
Funding Agency and Grant Number
Corresponding author Dr. Alan Prem Kumar, PhD, Cancer Science Institute of Singapore, National University of Singapore, Singapore City 117597, Singapore. csiapk@nus.edu.sg
Keywords Epidemiology; Gastric cancer; PI3K/Akt/mTOR pathway; Predictive biomarkers; Targeted therapy
Core Tip Gastric cancer (GC) is the fifth most common cancer in the world with highest incidence rate in Eastern Asia and Latin America. With increase in GC patient relapse and drug resistance, targeted therapy is gaining immense popularity for GC treatment. One of the pathways which has been reported to be dysregulated is phosphoinositide-3-kinase B (PI3K)/Akt signaling pathway. This review focuses on how this pathway is crucial in GC oncogenesis. We also summarize the single or dual PI3K/Akt pathway inhibitors under investigation for GC treatment. Thereby, we discuss the plausible novel biomarkers under investigation for a more tailored approach for GC treatment.
Publish Date 2015-11-18 12:39
Citation Singh SS, Yap WN, Arfuso F, Kar S, Wang C, Cai W, Dharmarajan AM, Sethi G, Kumar AP. Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine? World J Gastroenterol 2015; 21(43): 12261-12273
Url http://www.wjgnet.com/1007-9327/full/v21/i43/12261.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i43.12261
Full Article (PDF) WJG-21-12261.pdf
Full Article (Word) WJG-21-12261.doc
Manuscript File 19956-Review.doc
Answering Reviewers 19956-Answering reviewers.pdf
Audio Core Tip 19956-Audio core tip.mp3
Copyright License Agreement 19956-Copyright assignment.pdf
Peer-review Report 19956-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 19956-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 19956-Scientific misconduct check.pdf
Scientific Editor Work List 19956-Scientific editor work list.pdf