Publication Name	World Journal of Gastroenterology
Manuscript ID	19974
Country	France

Received	2015-05-27 09:39
Peer-Review Started	2015-05-29 14:36
To Make the First Decision	2015-09-09 17:32
Return for Revision	2015-09-15 11:47
Revised	2015-10-02 15:25
Second Decision	2015-11-10 08:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-11-19 13:26
Articles in Press	2015-11-19 13:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-28 09:31
Publish the Manuscript Online	2016-01-15 14:54

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Immunology
Manuscript Type	Topic Highlights
Article Title	Disrupted regulatory T cell homeostasis in inflammatory bowel diseases
Manuscript Source	Invited Manuscript
All Author List	Christophe Pedros, Fanny Duguet, Abdelhadi Saoudi and Marianne Chabod
Funding Agency and Grant Number	Funding Agency Grant Number INSERM, Fondation pour la Recherche Médicale DEQ2000326531 Région Midi-Pyrénées Centre National de la Recherche Scientifique to Saoudi A
Corresponding Author	Marianne Chabod, PhD, Assistant Professor, Epidermis Differentiation and Rheumatoid Autoimmunity Laboratory, UMR CNRS 5165, INSERM U 1056, Toulouse III University, 118 Route de Narbonne, F-31300 Toulouse, France. marianne.chabod@udear.cnrs.fr
Key Words	Regulatory T cells; Foxp3; Gut; Inflam­matory bowel disease; Colitis
Core Tip	The mucosal immune system must be very well-controlled to avoid immune responses against both microbial and innocuous food antigens. Regulatory T cells (Tregs) constitute a key mechanism to ensure gut homeostasis. In this review, both Treg biology and the suppressive mechanisms that have been identified using animal models of intestinal inflammation are first summarized. Then, we discuss the current knowledge concerning their contribution to human inflammatory bowel diseases (IBDs). Interestingly, these relatively recent advances have led to new therapeutic per-spectives for IBD treatment by targeting this potent immunosuppressive cell population.
Publish Date	2016-01-15 14:54
Citation	Pedros C, Duguet F, Saoudi A, Chabod M. Disrupted regulatory T cell homeostasis in inflammatory bowel diseases. World J Gastroenterol 2016; 22(3): 974-995
URL	http://www.wjgnet.com/1007-9327/full/v22/i3/974.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i3.974

Full Article (PDF)	WJG-22-974.pdf
Full Article (Word)	WJG-22-974.doc
Manuscript File	19974-Review.docx
Answering Reviewers	19974-Answering reviewers.pdf
Audio Core Tip	19974-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	19974-Conflict-of-interest statement.pdf
Copyright License Agreement	19974-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	19974-Language certificate.pdf
Peer-review Report	19974-Peer-review(s).pdf
Scientific Misconduct Check	19974-Scientific misconduct check.pdf
Scientific Editor Work List	19974-Scientific editor work list.pdf