Publication Name	World Journal of Gastroenterology
Manuscript ID	19995
Country	Chile

Received	2015-05-27 08:30
Peer-Review Started	2015-05-29 15:21
To Make the First Decision	2015-07-14 11:48
Return for Revision	2015-07-24 16:39
Revised	2015-08-08 04:03
Second Decision	2015-10-10 18:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-10-13 18:12
Articles in Press	2015-10-13 18:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-12 15:45
Publish the Manuscript Online	2015-12-06 13:18

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis
Manuscript Source	Invited Manuscript
All Author List	Manuel A Valenzuela, Jimena Canales, Alejandro H Corvalán and Andrew FG Quest
Funding Agency and Grant Number	Funding Agency Grant Number CONICYT-FONDAP project 15130011 (to Corvalánand AH and Quest AFG) FONDECYT project 1151411 (to Corvalán AH) CONICYT PhD fellowship award to Canales J
Corresponding Author	Andrew FG Quest, PhD, Cellular Communication Laboratory, Center for Molecular Studies of the Cell, Advanced Center for Chronic Diseases, School of Medicine, Universidad de Chile, Av. Independencia 1027, Santiago 8380453, Chile. aquest@med.uchile.cl
Key Words	Helicobacter pylori; Methylation; Gastric cancer; Epigenetics; MicroRNA
Core Tip	Helicobacter pylori infection increases the risk of developing gastric cancer. Intestinal type gastric cancer is characterized by a histological cascade in which aberrant methylation of CpG islands and deregulation of microRNAs are observed. An exacerbated host response and bacterial virulence factors contribute to these epigenetic changes by enhancing DNA methyl transferase activity via nitric oxide production and silencing of tumor suppressor genes and miRNAs. Interestingly, methylated Reprimo DNA is detectable in blood samples and is potentially useful as an early detection marker. Finally, also the role of gamma glutamyl transpeptidase related mechanisms in the loss of the anti-apoptotic protein Survivin and gastric carcinogenesis is discussed.
Publish Date	2015-12-06 13:18
Citation	Valenzuela MA, Canales J, Corvalán AH, Quest AFG. Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis. World J Gastroenterol 2015; 21(45): 12742-12756
URL	http://www.wjgnet.com/1007-9327/full/v21/i45/12742.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i45.12742

Full Article (PDF)	WJG-21-12742.pdf
Full Article (Word)	WJG-21-12742.doc
Manuscript File	19995-Review.doc
Answering Reviewers	19995-Answering reviewers.pdf
Audio Core Tip	19995-Audio core tip.mp3
Copyright License Agreement	19995-Copyright assignment.pdf
Peer-review Report	19995-Peer-review(s).pdf
Scientific Misconduct Check	19995-Scientific misconduct check.pdf
Scientific Editor Work List	19995-Scientific editor work list.pdf