Publication Name	World Journal of Orthopedics
Manuscript ID	20010
Country	Spain

Received	2015-05-27 20:27
Peer-Review Started	2015-05-30 11:31
To Make the First Decision	2015-07-27 15:48
Return for Revision	2015-08-04 10:31
Revised	2015-08-22 23:06
Second Decision	2015-10-08 12:20
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-10-19 15:23
Articles in Press	2015-10-19 15:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-01 17:17
Publish the Manuscript Online	2015-12-17 21:04

ISSN	2218-5836 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Orthopedics
Manuscript Type	Review
Article Title	Use of antibiotic-loaded cement in total knee arthroplasty
Manuscript Source	Invited Manuscript
All Author List	Pedro Hinarejos, Pau Guirro, Lluis Puig-Verdie, Raul Torres-Claramunt, Joan Leal-Blanquet, Juan Sanchez-Soler and Joan Carles Monllau
Funding Agency and Grant Number
Corresponding Author	Pedro Hinarejos, MD, PhD, Department of Orthopedic Surgery, Hospital del Mar, Universitat Autònoma de Barcelona, Sant Josep de la Muntanya 12, 08024 Barcelona, Spain. phinarejos@parcdesalutmar.cat
Key Words	Antibiotic loaded cement; Antibiotic toxicity; Total knee arthroplasty; Infection; Prophylaxis; Economic cost; Antimicrobial resistance
Core Tip	The bone cement capacity to release antibiotic molecules has been helpful in the treatment of prosthetic infections. Many authors have recommended the use of antibiotic loaded bone cement (ALBC) in total knee arthroplasty (TKA) for infection prophylaxis, but the actual evidence suggests a minimal, if any, protective effect against infection in TKA. There are some concerns against its routine use in primary TKA: The risk of toxicity, possible mechanical properties reduction, a significant increase in the cost of the cement, and the risk of selection of antibiotic-resistant bacteria. We recommend a cautious use of ALBC, perhaps only in high-risk patients, unless its benefits were better proven.
Publish Date	2015-12-17 21:04
Citation	Hinarejos P, Guirro P, Puig-Verdie L, Torres-Claramunt R, Leal-Blanquet J, Sanchez-Soler J, Monllau JC. Use of antibiotic-loaded cement in total knee arthroplasty. World J Orthop 2015; 6(11): 877-885
URL	http://www.wjgnet.com/2218-5836/full/v6/i11/877.htm
DOI	http://dx.doi.org/10.5312/wjo.v6.i11.877

Full Article (PDF)	WJO-6-877.pdf
Full Article (Word)	WJO-6-877.doc
Manuscript File	20010-Review.doc
Answering Reviewers	20010-Answering reviewers.pdf
Audio Core Tip	20010-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20010-Conflict-of-interest statement.pdf
Copyright License Agreement	20010-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	20010-Language certificate.pdf
Peer-review Report	20010-Peer-review(s).pdf
Scientific Misconduct Check	20010-Scientific misconduct check.pdf
Scientific Editor Work List	20010-Scientific editor work list.pdf