Publication Name	World Journal of Biological Chemistry
Manuscript ID	20018
Country	Japan

Received	2015-05-27 20:41
Peer-Review Started	2015-05-30 11:49
To Make the First Decision	2015-06-18 15:11
Return for Revision	2015-06-25 16:47
Revised	2015-07-22 16:59
Second Decision	2015-09-02 10:32
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-09-16 18:40
Articles in Press	2015-09-16 18:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-03 07:25
Publish the Manuscript Online	2015-11-23 10:19

ISSN	1949-8454 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Basic Study
Article Title	JAK3 inhibitor Ⅵ is a mutant specific inhibitor for epidermal growth factor receptor with the gatekeeper mutation T790M
Manuscript Source	Invited Manuscript
All Author List	Naoyuki Nishiya, Yasumitsu Sakamoto, Yusuke Oku, Takamasa Nonaka and Yoshimasa Uehara
Funding Agency and Grant Number
Corresponding Author	Naoyuki Nishiya, PhD, Department of Microbial Chemical Biology and Drug Discovery, Iwate Medical University School of Pharmacy, 2-1-1 Nishitokuta, Yahaba-cho, Shiwa-gun, Iwate 028-3694, Japan. nnishiya@iwate-med.ac.jp
Key Words	Epidermal growth factor receptor; Tyrosine kinase inhibitor; Gatekeeper mutation; Non-small cell lung cancers
Core Tip	Non-small cell lung cancers caused by mutations in the epidermal growth factor receptor (EGFR) initially respond to tyrosine kinase inhibitors (TKIs). However, the therapeutic efficacy of EGFR-TKIs is limited by drug-resistant mutations such as the gatekeeper mutation T790M. Our present study rediscovered JAK3 inhibitor Ⅵ, a known TKI for Janus kinases (JAKs), as a selective EGFR T790M inhibitor. Our structural analysis revealed similarities among EGFR T790M and JAKs, offering a possible strategy to search for EGFR T790M inhibitors from known kinase inhibitors. Repositioning of the existing therapeutics may facilitate solving clinical problems such as drug resistance and toxicity.
Publish Date	2015-11-23 10:19
Citation	Nishiya N, Sakamoto Y, Oku Y, Nonaka T, Uehara Y. JAK3 inhibitor Ⅵ is a mutant specific inhibitor for epidermal growth factor receptor with the gatekeeper mutation T790M. World J Biol Chem 2015; 6(4): 409-418
URL	http://www.wjgnet.com/1949-8454/full/v6/i4/409.htm
DOI	http://dx.doi.org/10.4331/wjbc.v6.i4.409

Full Article (PDF)	WJBC-6-409.pdf
Full Article (Word)	WJBC-6-409.doc
Manuscript File	20018-Review.docx
Answering Reviewers	20018-Answering reviewers.pdf
Audio Core Tip	20018-Audio core tip.mp3
Biostatistics Review Certificate	20018-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	20018-Conflict-of-interest statement.pdf
Copyright License Agreement	20018-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	20018-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	20018-Instutitional review boad statement.pdf
Non-Native Speakers of English Editing Certificate	20018-Language certificate.pdf
Peer-review Report	20018-Peer-review(s).pdf
Scientific Misconduct Check	20018-Scientific misconduct check.pdf
Scientific Editor Work List	20018-Scientific editor work list.pdf