Publication Name	World Journal of Clinical Oncology
Manuscript ID	20026
Country	Italy

Received	2015-05-28 11:00
Peer-Review Started	2015-05-30 13:07
To Make the First Decision	2015-07-03 16:46
Return for Revision	2015-07-10 19:11
Revised	2015-08-06 17:36
Second Decision	2015-09-21 17:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-09-30 18:37
Articles in Press	2015-09-30 18:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-29 16:03
Publish the Manuscript Online	2015-12-09 18:37

ISSN	2218-4333 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Editorial
Article Title	Inorganic phosphate in the development and treatment of cancer: A Janus Bifrons?
Manuscript Source	Invited Manuscript
All Author List	Luigi Sapio and Silvio Naviglio
Funding Agency and Grant Number
Corresponding Author	Silvio Naviglio, MD, PhD, Department of Biochemistry, Biophysics and General Pathology, Medical School, Second University of Naples, Via L. De Crecchio 7, 80138 Naples, Italy. silvio.naviglio@unina2.it
Key Words	Calcium-phosphate nanoparticles; Inorganic phosphate; Cancer; High-phosphorus diets; Phosphorus intake; Doxorubicin; Combination therapy; Naturally occurring molecule; Osteosarcoma
Core Tip	Many chronic diseases, including cancer have been proposed to be associated with high-phosphorus intakes and high-serum inorganic phosphate (Pi) concen-trations. On the other hand, there is also evidence that Pi can have antiproliferative effects on some cancer cell types, depending on cell status and genetic background and achieve additive cytotoxic effects when combined with doxorubicin, illustrating its potential for clinical applications and suggesting that up-regulating Pi levels at local sites for brief times, might contribute to the development of novel and cheap modalities for therapeutic intervention in some tumors, including triple-negative breast cancer and osteosarcoma.
Publish Date	2015-12-09 18:37
Citation	Sapio L, Naviglio S. Inorganic phosphate in the development and treatment of cancer: A Janus Bifrons? World J Clin Oncol 2015; 6(6): 198-201
URL	http://www.wjgnet.com/2218-4333/full/v6/i6/198.htm
DOI	http://dx.doi.org/10.5306/wjco.v6.i6.198

Full Article (PDF)	WJCO-6-198.pdf
Full Article (Word)	WJCO-6-198.doc
Manuscript File	20026-Review.doc
Answering Reviewers	20026-Answering reviewers.pdf
Audio Core Tip	20026-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20026-Conflict-of-interest statement.pdf
Copyright License Agreement	20026-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	20026-Language certificate.pdf
Peer-review Report	20026-Peer-review(s).pdf
Scientific Misconduct Check	20026-Scientific misconduct check.pdf
Scientific Editor Work List	20026-Scientific editor work list.pdf