Publication Name	World Journal of Hepatology
Manuscript ID	20071
Country	Brazil

Received	2015-05-28 08:34
Peer-Review Started	2015-06-01 13:40
To Make the First Decision	2015-07-27 18:38
Return for Revision	2015-08-01 18:00
Revised	2015-08-11 19:53
Second Decision	2015-10-21 17:31
Accepted by Journal Editor-in-Chief	2015-10-21 18:13
Accepted by Executive Editor-in-Chief	2015-11-04 17:36
Articles in Press	2015-11-04 17:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-10 18:57
Publish the Manuscript Online	2015-11-18 11:12

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Wnt-/-β-catenin pathway signaling in human hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Jaques Waisberg and Gabriela Tognini Saba
Funding Agency and Grant Number
Corresponding Author	Jaques Waisberg, MD, PhD, FACS, Professor, Head, Department of Surgery, ABC Medical School, Santo André, São Paulo 09060-650, Brazil. jaqueswaisberg@uol.com.br
Key Words	Carcinoma; Hepatocellular; Wnt signaling pathway; Beta catenin; Wnt proteins; Receptors
Core Tip	The Wnt signaling pathway is decisive in the rule of mechanisms of proliferation and survival, as well as the differentiation of liver cells during hepatic embryogenesis and morphogenesis. The atypical initiation of signaling in the hepatocellular carcinoma (HCC) is primarily because of deregulated expressions of the components of the Wnt-/-β-catenin. The mechanisms that are considered more functional and that sustain aberrant activation of signaling pathways act via alte-rations in the β-catenin gene or the AXIN1/2-gene’s encoding axin, a protein necessary for the degradation of β-catenin. The development of targeted therapeutic molecules for the blockade of the Wnt-signaling pathway for the treatment of HCC depends on the identification of molecules that would be effective only in tumor cells that carry an aberrant signaling β-catenin.
Publish Date	2015-11-18 11:12
Citation	Waisberg J, Saba GT. Wnt-/-β-catenin pathway signaling in human hepatocellular carcinoma. World J Hepatol 2015; 7(26): 2631-2635
URL	http://www.wjgnet.com/1948-5182/full/v7/i26/2631.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i26.2631

Full Article (PDF)	WJH-7-2631.pdf
Full Article (Word)	WJH-7-2631.doc
Manuscript File	20071-Review.docx
Answering Reviewers	20071-Answering reviewers.pdf
Audio Core Tip	20071-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20071-Conflict-of-interest statement.pdf
Copyright License Agreement	20071-Copyright assignment.pdf
Peer-review Report	20071-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	20071-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	20071-Scientific misconduct check.pdf
Scientific Editor Work List	20071-Scientific editor work list.pdf