Publication Name	World Journal of Orthopedics
Manuscript ID	20072
Country	Ireland

Received	2015-05-28 08:33
Peer-Review Started	2015-06-01 13:42
To Make the First Decision	2015-07-27 15:49
Return for Revision	2015-08-04 11:17
Revised	2015-08-14 20:16
Second Decision	2015-09-21 17:32
Accepted by Journal Editor-in-Chief	2015-09-21 22:25
Accepted by Executive Editor-in-Chief	2015-10-08 18:08
Articles in Press	2015-10-08 18:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-02 11:48
Publish the Manuscript Online	2015-12-17 21:04

ISSN	2218-5836 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Orthopedics
Manuscript Type	Retrospective Cohort Study
Article Title	Cost benefit analysis of the use of tranexamic acid in primary lower limb arthroplasty: A retrospective cohort study
Manuscript Source	Invited Manuscript
All Author List	Niall P McGoldrick, Eabhann M O’Connor, Nikos Davarinos, Rose Galvin and John F Quinlan
Funding Agency and Grant Number
Corresponding Author	Niall P McGoldrick, MB, MCh, MRCSI, Department of Trauma and Orthopaedic Surgery, Tallaght Hospital, Belgard Square North, Dublin D24 NR0A, Ireland. niallmcg@gmail.com
Key Words	Arthroplasty; Hip; Knee; Tranexamic acid; Cost-benefit analysis
Core Tip	Worldwide the demand for lower limb arthroplasty procedures is increasing in the context of a diminishing economic climate. Total hip replacement and total knee replacement have traditionally been associated with large volume blood loss and the need for transfusion. Use of perioperative intravenous tranexamic acid (TXA) has been shown to be a cost effective measure, which reduces the need for transfusion. In this study, TXA was found to significantly reduce the number of patients requiring blood transfusion post-operatively, which has both clinical and economic significance.
Publish Date	2015-12-17 21:04
Citation	McGoldrick NP, O’Connor EM, Davarinos N, Galvin R, Quinlan JF. Cost benefit analysis of the use of tranexamic acid in primary lower limb arthroplasty: A retrospective cohort study. World J Orthop 2015; 6(11): 977-982
URL	http://www.wjgnet.com/2218-5836/full/v6/i11/977.htm
DOI	http://dx.doi.org/10.5312/wjo.v6.i11.977

Full Article (PDF)	WJO-6-977.pdf
Full Article (Word)	WJO-6-977.doc
Manuscript File	20072-Review.docx
Answering Reviewers	20072-Answering reviewers.PDF
Audio Core Tip	20072-Audio core tip.mp4
Biostatistics Review Certificate	20072-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	20072-Conflict-of-interest statement.pdf
Copyright License Agreement	20072-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	20072-Institutional review board statement.pdf
Peer-review Report	20072-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	20072-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	20072-Scientific misconduct check.pdf
Scientific Editor Work List	20072-Scientific editor work list.pdf