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Articles Published Processes
12/25/2015 8:04:00 AM | Browse: 1058 | Download: 2185
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Received |
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2015-05-28 16:08 |
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Peer-Review Started |
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2015-06-01 14:13 |
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To Make the First Decision |
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2015-09-16 09:10 |
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Return for Revision |
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2015-09-17 16:36 |
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Revised |
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2015-10-03 06:32 |
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Second Decision |
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2015-11-09 10:55 |
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Accepted by Journal Editor-in-Chief |
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2015-11-10 07:26 |
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Accepted by Executive Editor-in-Chief |
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2015-11-25 15:46 |
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Articles in Press |
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2015-11-25 15:46 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-12-16 10:49 |
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Publish the Manuscript Online |
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2015-12-25 08:04 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Induction of CXC chemokines in human mesenchymal stem cells by stimulation with secreted frizzled-related proteins through non-canonical Wnt signaling
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| Manuscript Source |
Invited Manuscript |
| All Author List |
David S Bischoff, Jian-Hua Zhu, Nalini S Makhijani and Dean T Yamaguchi |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Department of Veterans Affairs Biomedical Laboratory Research and Development Service of the VA Office of Research and Development, United States |
I01BX000170 |
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| Corresponding Author |
Dean T Yamaguchi, MD, PhD, Associate Chief of Staff, Research Service, VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd, Building, Los Angeles, CA 91343, United States. dean.yamaguchi@va.gov
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| Key Words |
CXC chemokines; Mesenchymal stem cell; Osteogenesis; Differentiation; Wnt signaling pathway; Frizzled-related protein; Frizzled receptors |
| Core Tip |
Chemokines have multiple functions during bone formation and fracture repair. The ELR+ chemo-kines classically have a role in blood vessel formation and were found to be stimulated by the non-canonical Wnt5a protein and also by soluble frizzled-related proteins (sFRPs) that are known inhibitors of both canonical and non-canonical Wnt signaling. This stimulation was mediated via the p44/42 extracellular signal-regulated kinase and phospholipase C pathways signaling through the non-canonical frizzled receptors 2 and 5. This is a newly identified role for the sFRPs in stimulation of ELR+ chemokines which may be involved in blood vessel formation during wound repair.
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| Publish Date |
2015-12-25 08:04 |
| Citation |
Bischoff DS, Zhu JH, Makhijani NS, Yamaguchi DT. Induction of CXC chemokines in human mesenchymal stem cells by stimulation with secreted frizzled-related proteins through non-canonical Wnt signaling. World J Stem Cells 2015; 7(11): 1262-1273 |
| URL |
http://www.wjgnet.com/1948-0210/full/v7/i11/1262.htm |
| DOI |
http://dx.doi.org/10.4252/wjsc.v7.i11.1262 |
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