Publication Name	World Journal of Gastroenterology
Manuscript ID	20094
Country	China

Received	2015-05-28 16:23
Peer-Review Started	2015-05-31 14:22
To Make the First Decision	2015-08-26 15:10
Return for Revision	2015-08-31 19:32
Revised
Second Decision	2015-10-23 16:29
Accepted by Journal Editor-in-Chief	2015-10-25 21:10
Accepted by Company Editor-in-Chief	2015-11-09 17:13
Articles in Press	2015-11-09 17:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-01 16:45
Publish the Manuscript Online	2015-12-15 12:22

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Letter to the Editor
Article Title	Current status of superparamagnetic iron oxide contrast agents for liver magnetic resonance imaging
Manuscript Source	Unsolicited Manuscript
All Author List	Yi-Xiang J Wang
Funding Agency and Grant Number
Corresponding Author	Yi-Xiang J Wang, PhD, MMed, Department of Imaging and Interventional Radiology, Faculty of Medicine, the Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China. yixiang_wang@cuhk.edu.hk
Key Words	Superparamagnetic iron oxide; liver; hepa­tocellular carcinoma; magnetic resonance imaging; Resovist; Gd-EOB-DTPA; Primovist; Eovist
Core Tip	Superparamagnetic iron oxide nanoparticle for liver imaging was conceptualized when the speed of both single-slice computed tomography (CT) scan and multiple-slice magnetic resonance imaging (MRI) was slow. It was difficult to accurately observe the “wash-in” and “wash-out” of liver lesion blood flow dynamics. However, recently spiral CT and later multi-slice CT revolutionized liver imaging. MRI scan is also currently much faster due to the improved gradient technology and fast data acquisition sequences. These techniques increased the sensitivity and specificity of dynamic imaging using small molecular agents such as iodinated CT contrast agents and Gadolinium based MRI contrast agents. Gd-EOB-DTPA-enhanced liver MRI is currently emerging as the leading method for diagnosis and staging of hepatocellular carcinoma.
Publish Date	2015-12-15 12:22
Citation	Wang YXJ. Current status of superparamagnetic iron oxide contrast agents for liver magnetic resonance imaging. World J Gastroenterol 2015; 21(47): 13400-13402
URL	http://www.wjgnet.com/1007-9327/full/v21/i47/13400.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i47.13400

Full Article (PDF)	WJG-21-13400.pdf
Full Article (Word)	WJG-21-13400.doc
Manuscript File	20094-Review.doc
Answering Reviewers	20094-Answering reviewers.pdf
Audio Core Tip	20094-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20094-Conflict-of-interest statement.pdf
Copyright License Agreement	20094-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	20094-Language certificate.pdf
Peer-review Report	20094-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	20094-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	20094-Scientific misconduct check.pdf
Scientific Editor Work List	20094-Scientific editor work list.pdf