Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	20112
Country	Italy

Received	2015-05-28 17:04
Peer-Review Started	2015-05-28 21:47
To Make the First Decision	2015-07-02 13:33
Return for Revision	2015-07-10 15:02
Revised	2015-07-21 00:00
Second Decision	2015-10-08 12:21
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-10-19 15:25
Articles in Press	2015-10-19 15:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-23 16:32
Publish the Manuscript Online	2015-11-17 12:17

ISSN	2150-5330 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Starring role of toll-like receptor-4 activation in the gut-liver axis
Manuscript Source	Invited Manuscript
All Author List	Simone Carotti, Michele Pier Luca Guarino, Umberto Vespasiani-Gentilucci and Sergio Morini
Funding Agency and Grant Number
Corresponding Author	Sergio Morini, MD, Laboratory of Microscopic and Ultrastructural Anatomy, School of Medicine, University Campus Bio-Medico of Rome, Via Alvaro Del Portillo, 21, 00128 Rome, Italy. s.morini@unicampus.it
Key Words	Gut microbiota; Dysbiosis; Toll-like receptor 4; Gut motility; Lipopolysaccharide tolerance; Non-alcoholic fatty liver disease; Chronic hepatitis; Intestinal barrier function; Liver fibrosis
Core Tip	Liver disease is associated with significant changes in intestinal microbiota, but whether liver disease modifies the complement of gut bacteria or dysbiosis causes liver disease is not clearly understood. This review outlines current knowledge on the gut-liver axis, with a particular focus on the role of toll-like receptor 4 activation in functional gastrointestinal disorders, liver inflammation and fibrosis.
Publish Date	2015-11-17 12:17
Citation	Carotti S, Guarino MPL, Vespasiani-Gentilucci U, Morini S. Starring role of toll-like receptor-4 activation in the gut-liver axis. World J Gastrointest Pathophysiol 2015; 6(4): 99-109
URL	http://www.wjgnet.com/2150-5330/full/v6/i4/99.htm
DOI	http://dx.doi.org/10.4291/wjgp.v6.i4.99

Full Article (PDF)	WJGP-6-99.pdf
Full Article (Word)	WJGP-6-99.doc
Manuscript File	20112-Review.docx
Answering Reviewers	20112-Answering reviewers.pdf
Audio Core Tip	20112-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	20112-Conflict-of-interest statement.pdf
Copyright License Agreement	20112-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	20112-Language certificate.pdf
Peer-review Report	20112-Peer-review(s).pdf
Scientific Misconduct Check	20112-Scientific misconduct check.pdf
Scientific Editor Work List	20112-Scientific editor work list.pdf