Publication Name	World Journal of Biological Chemistry
Manuscript ID	20114
Country	Spain

Received	2015-05-28 17:16
Peer-Review Started	2015-05-28 21:42
To Make the First Decision	2015-06-18 16:15
Return for Revision	2015-07-20 19:48
Revised	2015-07-31 19:34
Second Decision	2015-08-27 11:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-09-08 15:26
Articles in Press	2015-09-08 15:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-03 07:24
Publish the Manuscript Online	2015-11-23 10:19

ISSN	1949-8454 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Minireviews
Article Title	Klotho in cardiovascular disease: Current and future perspectives
Manuscript Source	Invited Manuscript
All Author List	Javier Donate-Correa, Ernesto Martín-Núñez, Carmen Mora-Fernández, Mercedes Muros-de-Fuentes, Nayra Pérez-Delgado and Juan F Navarro-González
Funding Agency and Grant Number
Corresponding Author	Javier Donate-Correa, PhD, Research Unit, University Hospital Nuestra Señora de Candelaria, Ctra. Gral. del Rosario, 145, 38010 Santa Cruz de Tenerife, Spain. jdonate@ull.es
Key Words	Klotho; Cardiovascular disease; Chronic kidney disease; Mechanism of action; Therapeutics
Core Tip	Protein Klotho, beyond its role as a regulator of the phosphatemia, has also been involved in the maintaining of the cardiovascular health. For all this, is the subject of a thorough research which focused on uncover its intimate mechanisms of action, and in analyzing the utility of its modulation as a potential strategy for clinical applicability. Emerging research links Klotho deficiency with vascular pathology. Changes in this protein have been associated, among others cardiovascular-related complications, with inflammation, vascular calcification, and endothelial dysfunction.
Publish Date	2015-11-23 10:19
Citation	Donate-Correa J, Martín-Núñez E, Mora-Fernández C, Muros-de-Fuentes M, Pérez-Delgado N, Navarro-González JF. Klotho in cardiovascular disease: Current and future perspectives. World J Biol Chem 2015; 6(4): 351-357
URL	http://www.wjgnet.com/1949-8454/full/v6/i4/351.htm
DOI	http://dx.doi.org/10.4331/wjbc.v6.i4.351

Full Article (PDF)	WJBC-6-351.pdf
Full Article (Word)	WJBC-6-351.doc
Manuscript File	20114-Review.doc
Answering Reviewers	20114-Answering reviewers.pdf
Audio Core Tip	20114-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20114-Conflict-of-interest statement.pdf
Copyright License Agreement	20114-Copyright assignment.PDF
Non-Native Speakers of English Editing Certificate	20114-Language certificate.pdf
Peer-review Report	20114-Peer-review(s).pdf
Scientific Misconduct Check	20114-Scientific misconduct check.pdf
Scientific Editor Work List	20114-Scientific editor work list.pdf