Publication Name	World Journal of Biological Chemistry
Manuscript ID	20116
Country	Japan

Received	2015-05-29 09:12
Peer-Review Started	2015-05-30 11:04
To Make the First Decision	2015-07-28 10:42
Return for Revision	2015-08-07 20:31
Revised	2015-08-31 20:45
Second Decision	2015-09-21 17:08
Accepted by Journal Editor-in-Chief	2015-09-22 06:41
Accepted by Executive Editor-in-Chief	2015-09-30 18:22
Articles in Press	2015-09-30 18:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-03 07:24
Publish the Manuscript Online	2015-11-23 10:19

ISSN	1949-8454 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Biochemistry & Molecular Biology
Manuscript Type	Minireviews
Article Title	Caldecrin: A pancreas-derived hypocalcemic factor, regulates osteoclast formation and function
Manuscript Source	Invited Manuscript
All Author List	Mineko Tomomura and Akito Tomomura
Funding Agency and Grant Number
Corresponding Author	Mineko Tomomura, PhD, Associate Professor, Meikai Pharmaco-Medical Laboratory, MPL and Division of Biochemistry, Department of Oral Biology and Tissue Engineering, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama 350-0283, Japan. mineko-t@dent.meikai.ac.jp
Key Words	Serine protease; Osteoclasts; Hypocalcemia; Chymotrypsin; Bone resorption; Calcium signaling
Core Tip	Caldecrin (also known as chymotrypsin C) reduces serum calcium levels. This activity is distinct from its protease activity but also requires trypsin-mediated cleavage of the pro-peptide, converting caldecrin to its active form. Ectopic intramuscular expression of caldecrin prevented bone resorption in ovariectomized mice. Caldecrin inhibited parathyroid hormone-stimulated calcium release from fetal mouse long bones. Furthermore, caldecrin suppressed receptor activator of nuclear factor-kappa B ligand-induced activation of intracellular calcium signaling, thereby reducing osteoclast formation and bone resorption. Caldecrin is a unique multifunctional protease that possesses anti-osteoclastogenic activity, resulting in reduced serum calcium levels.
Publish Date	2015-11-23 10:19
Citation	Tomomura M, Tomomura A. Caldecrin: A pancreas-derived hypocalcemic factor, regulates osteoclast formation and function. World J Biol Chem 2015; 6(4): 358-365
URL	http://www.wjgnet.com/1949-8454/full/v6/i4/358.htm
DOI	http://dx.doi.org/10.4331/wjbc.v6.i4.358

Full Article (PDF)	WJBC-6-358.pdf
Full Article (Word)	WJBC-6-358.doc
Manuscript File	20116-Review.docx
Answering Reviewers	20116-Answering reviewers.pdf
Audio Core Tip	20116-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20116-Conflict-of-interest statement.pdf
Copyright License Agreement	20116-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	20116-Language certificate.pdf
Peer-review Report	20116-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	20116-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	20116-Scientific misconduct check.pdf
Scientific Editor Work List	20116-Scientific editor work list.pdf