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11/23/2015 11:10:00 AM | Browse: 384 | Download: 625
Publication Name World Journal of Biological Chemistry
Manuscript ID 20116
Country of Manuscript Source Japan
2015-05-29 09:12
Peer-Review Started
2015-05-30 11:04
To Make the First Decision
2015-07-28 10:42
Return for Revision
2015-08-07 20:31
2015-08-31 20:45
Second Decision
2015-09-21 17:08
Accepted by Journal Editor-in-Chief
2015-09-22 06:41
Accepted by Company Editor-in-Chief
2015-09-30 18:22
Articles in Press
2015-09-30 18:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-11-03 07:24
Publish the Manuscript Online
2015-11-23 10:19
ISSN 1949-8454 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biochemistry and Molecular Biology
Manuscript Type Minireviews
Article Title Caldecrin: A pancreas-derived hypocalcemic factor, regulates osteoclast formation and function
Manuscript Source Invited Manuscript
All Author List Mineko Tomomura and Akito Tomomura
Funding Agency and Grant Number
Corresponding author Mineko Tomomura, PhD, Associate Professor, Meikai Pharmaco-Medical Laboratory, MPL and Division of Biochemistry, Department of Oral Biology and Tissue Engineering, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama 350-0283, Japan. mineko-t@dent.meikai.ac.jp
Keywords Serine protease; Osteoclasts; Hypocalcemia; Chymotrypsin; Bone resorption; Calcium signaling
Core Tip Caldecrin (also known as chymotrypsin C) reduces serum calcium levels. This activity is distinct from its protease activity but also requires trypsin-mediated cleavage of the pro-peptide, converting caldecrin to its active form. Ectopic intramuscular expression of caldecrin prevented bone resorption in ovariectomized mice. Caldecrin inhibited parathyroid hormone-stimulated calcium release from fetal mouse long bones. Furthermore, caldecrin suppressed receptor activator of nuclear factor-kappa B ligand-induced activation of intracellular calcium signaling, thereby reducing osteoclast formation and bone resorption. Caldecrin is a unique multifunctional protease that possesses anti-osteoclastogenic activity, resulting in reduced serum calcium levels.
Publish Date 2015-11-23 10:19
Citation Tomomura M, Tomomura A. Caldecrin: A pancreas-derived hypocalcemic factor, regulates osteoclast formation and function. World J Biol Chem 2015; 6(4): 358-365
Url http://www.wjgnet.com/1949-8454/full/v6/i4/358.htm
DOI http://dx.doi.org/10.4331/wjbc.v6.i4.358
Full Article (PDF) WJBC-6-358.pdf
Full Article (Word) WJBC-6-358.doc
Manuscript File 20116-Review.docx
Answering Reviewers 20116-Answering reviewers.pdf
Audio Core Tip 20116-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 20116-Conflict-of-interest statement.pdf
Copyright License Agreement 20116-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 20116-Language certificate.pdf
Peer-review Report 20116-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 20116-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 20116-Scientific misconduct check.pdf
Scientific Editor Work List 20116-Scientific editor work list.pdf