Publication Name	World Journal of Cardiology
Manuscript ID	20121
Country	Germany

Received	2015-05-29 09:22
Peer-Review Started	2015-05-31 11:03
To Make the First Decision	2015-08-16 16:57
Return for Revision	2015-08-20 15:18
Revised	2015-08-28 01:53
Second Decision	2015-09-24 17:21
Accepted by Journal Editor-in-Chief	2015-09-24 22:18
Accepted by Executive Editor-in-Chief	2015-10-13 17:44
Articles in Press	2015-10-13 17:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-11 11:24
Publish the Manuscript Online	2015-12-24 17:39

ISSN	1949-8462 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Review
Article Title	Diagnostic and prognostic value of circulating microRNAs in heart failure with preserved and reduced ejection fraction
Manuscript Source	Invited Manuscript
All Author List	Christian Schulte, Dirk Westermann, Stefan Blankenberg and Tanja Zeller
Funding Agency and Grant Number	Funding Agency Grant Number European Union, BiomarCaRE HEALTH-2011-278913
Corresponding Author	Tanja Zeller, PhD, professor for Genomics and Systems Biology, Department of General and Interventional Cardiology, University Heart Center Hamburg Eppendorf, Building N27, Martinistr 52, 20246 Hamburg, Germany. t.zeller@uke.de
Key Words	microRNA; heart failure; cardiac fibrosis; biomarker; diagnostic; prognostic; heart failure with reduced ejection fraction; heart failure with preserved ejection fraction
Core Tip	Recent study results suggest microRNAs (miRNAs) as promising biomarkers in the diagnosis of heart failure (HF) with reduced ejection fraction (HFrEF) and with preserve ejection fraction (HFpEF). The therapeutic application of antagomirs and mirmimics in heart failure is still in its infancy but promising experimental results are reported. This review provides an overview of miRNAs as diagnostic and prognostic biomarkers in HF and gives details on the utilization of miRNAs in the differentiated diagnosis of HFpEF and HFrEF. The manuscript evaluates the therapeutic applicability of miRNAs in HF and thus provides valuable information for researchers dealing with miRNAs in HF.
Publish Date	2015-12-24 17:39
Citation	Schulte C, Westermann D, Blankenberg S, Zeller T. Diagnostic and prognostic value of circulating microRNAs in heart failure with preserved and reduced ejection fraction. World J Cardiol 2015; 7(12): 843-860
URL	http://www.wjgnet.com/1949-8462/full/v7/i12/843.htm
DOI	http://dx.doi.org/10.4330/wjc.v7.i12.843

Full Article (PDF)	WJC-7-843.pdf
Full Article (Word)	WJC-7-843.doc
Manuscript File	20121-Review.docx
Answering Reviewers	20121-Answering reviewers.pdf
Audio Core Tip	20121-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20121-Conflict-of-interest statement.pdf
Copyright License Agreement	20121-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	20121-Language certificate.pdf
Peer-review Report	20121-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	20121-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	20121-Scientific misconduct check.pdf
Scientific Editor Work List	20121-Scientific editor work list.pdf