Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	20128
Country	Greece

Received	2015-05-29 09:37
Peer-Review Started	2015-06-01 07:58
To Make the First Decision	2015-10-14 11:19
Return for Revision	2015-10-15 10:26
Revised	2015-10-20 17:41
Second Decision	2015-11-23 17:58
Accepted by Journal Editor-in-Chief	2015-11-23 23:06
Accepted by Executive Editor-in-Chief	2015-12-04 16:10
Articles in Press	2015-12-04 16:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-18 20:35
Publish the Manuscript Online	2016-01-29 11:06

ISSN	2150-5349 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Influence of environmental factors in the development of inflammatory bowel diseases
Manuscript Source	Invited Manuscript
All Author List	Evangelia Legaki and Maria Gazouli
Funding Agency and Grant Number	Funding Agency Grant Number Hellenic State Scholarships Foundation to Legaki E
Corresponding Author	Maria Gazouli, PhD, Assistant Professor, Department of Basic Medical Sciences, Laboratory of Biology, School of Medicine, University of Athens, Michalakopoulou 176, 11527 Athens, Greece. mgazouli@med.uoa.gr
Key Words	Crohn’s disease; Ulcerative colitis; Epigenetics; Environment
Core Tip	Epidemiological data, clinical observations and family/ immigrants studies indicate the significance of environmental influence in the development of inflammatory bowel diseases (IBD). A westernized high fat diet, full of refined carbohydrates is strongly associated with the development of IBD, contrary to a high in fruit, vegetables and polyunsaturated fatty acid-3 diet that is protective against these diseases. Additional factors such as air pollution, psychological factors, sleep disturbances and exercise influence the development and the course of IBD. Epigenetic mechanism like DNA methylation, histone modification and altered expression of miRNAS could explain the connection between genes and environmental factors in triggering the development of IBD.
Publish Date	2016-01-29 11:06
Citation	Legaki E, Gazouli M. Influence of environmental factors in the development of inflammatory bowel diseases. World J Gastrointest Pharmacol Ther 2016; 7(1): 112-125
URL	http://www.wjgnet.com/2150-5349/full/v7/i1/112.htm
DOI	http://dx.doi.org/10.4292/wjgpt.v7.i1.112

Full Article (PDF)	WJGPT-7-112.pdf
Full Article (Word)	WJGPT-7-112.doc
Manuscript File	20128-Review.doc
Answering Reviewers	20128-Answering reviewers.pdf
Audio Core Tip	20128-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	20128-Conflict-of-interest statement.pdf
Copyright License Agreement	20128-Copyright assignmet.pdf
Peer-review Report	20128-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	20128-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	20128-Scientific misconduct check.pdf
Scientific Editor Work List	20128-Scientific editor work list.pdf