Publication Name	World Journal of Gastroenterology
Manuscript ID	20131
Country	Japan

Received	2015-05-29 10:17
Peer-Review Started	2015-06-01 07:59
To Make the First Decision	2015-09-29 17:03
Return for Revision	2015-10-05 15:06
Revised	2015-10-20 00:42
Second Decision	2015-11-12 19:00
Accepted by Journal Editor-in-Chief	2015-11-12 22:13
Accepted by Executive Editor-in-Chief	2015-12-01 09:03
Articles in Press	2015-12-01 09:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-18 10:19
Publish the Manuscript Online	2016-01-06 16:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Minireviews
Article Title	Biomarkers of skin toxicity induced by anti-epidermal growth factor receptor antibody treatment in colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Akiko Kubo, Hironobu Hashimoto, Naoki Takahashi and Yasuhide Yamada
Funding Agency and Grant Number
Corresponding Author	Naoki Takahashi, MD, Gastrointestinal Oncology Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. naoki19800623@gmail.com
Key Words	Colorectal cancer; Skin toxicity; Epidermal growth factor receptor; Epidermal growth factor receptor polymorphism; Ligand
Core Tip	Skin toxicity is a well-known biomarker used in the prognosis of anti-epidermal growth factor receptor (EGFR) antibody treatment of colorectal cancer patients. Previous retrospective studies indicated a change of the polymorphism of EGFR intron-1, chemokines and ligands were predictive markers of skin toxicity induced by anti-EGFR antibody. Such biomarkers used in predicting skin toxicity will enable the earlier management of skin toxicity as well as improve patients’ quality of life; however, further validations of prospective studies are needed. For patients with no/mild skin toxicity, a clinical trial of a dose escalation strategy is under evaluation and ongoing in the form of the EVEREST 2 study.
Publish Date	2016-01-06 16:13
Citation	Kubo A, Hashimoto H, Takahashi N, Yamada Y. Biomarkers of skin toxicity induced by anti-epidermal growth factor receptor antibody treatment in colorectal cancer. World J Gastroenterol 2016; 22(2): 887-894
URL	http://www.wjgnet.com/1007-9327/full/v22/i2/887.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i2.887

Full Article (PDF)	WJG-22-887.pdf
Full Article (Word)	WJG-22-887.doc
Manuscript File	20131-Review.docx
Answering Reviewers	20131-Answering reviewers.pdf
Audio Core Tip	20131-Audio core tip.wma
Conflict-of-Interest Disclosure Form	20131-Conflict-of-interest statement.PDF
Copyright License Agreement	20131-Copyright assignment.PDF
Non-Native Speakers of English Editing Certificate	20131-Language certificate.pdf
Peer-review Report	20131-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	20131-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	20131-Scientific misconduct check.pdf
Scientific Editor Work List	20131-Scientific editor work list.pdf