Publication Name	World Journal of Gastroenterology
Manuscript ID	20154
Country	Japan

Received	2015-05-29 16:15
Peer-Review Started	2015-06-02 19:31
To Make the First Decision	2015-08-31 08:54
Return for Revision	2015-08-31 16:12
Revised	2015-10-14 00:47
Second Decision	2015-11-09 16:14
Accepted by Journal Editor-in-Chief	2015-11-10 14:00
Accepted by Executive Editor-in-Chief	2015-11-24 17:18
Articles in Press	2015-11-24 17:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-16 17:25
Publish the Manuscript Online	2015-12-31 13:27

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Chemoprevention of obesity-related liver carcinogenesis by using pharmaceutical and nutraceutical agents
Manuscript Source	Invited Manuscript
All Author List	Hiroyasu Sakai, Yohei Shirakami and Masahito Shimizu
Funding Agency and Grant Number
Corresponding Author	Hiroyasu Sakai, MD, PhD, Department of Gastroenterology/Internal Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan. sakaih03@gifu-u.ac.jp
Key Words	Hepatocellular carcinoma; Obesity; Green tea catechins; Branched-chain amino acids; Acyclic retinoid
Core Tip	Obesity and its related metabolic disorders increase the risk of hepatocellular carcinoma (HCC). In particular, the molecular abnormalities represented by insulin resistance/hyperinsulinemia, chronic inflammation, adipokine imbalance, and oxidative stress play a central role in the development of obesity-related HCC. Administration of green tea catechins, branched-chain amino acids, and acyclic retinoid has improved these metabolic abnormalities, and resulted in the inhibition of HCC development in obese and diabetic mice models. In this review, we highlight the possibility that nutraceutical and pharmaceutical approaches targeting metabolic abnormalities are a promising strategy to prevent the development of obesity-related HCC.
Publish Date	2015-12-31 13:27
Citation	Sakai H, Shirakami Y, Shimizu M. Chemoprevention of obesity-related liver carcinogenesis by using pharmaceutical and nutraceutical agents. World J Gastroenterol 2016; 22(1): 394-406
URL	http://www.wjgnet.com/1007-9327/full/v22/i1/394.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i1.394

Full Article (PDF)	WJG-22-394.pdf
Full Article (Word)	WJG-22-394.doc
Manuscript File	20154-Review.docx
Answering Reviewers	20154-Answering reviewers.pdf
Audio Core Tip	20154-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20154-Conflict-of-interest statement.pdf
Copyright License Agreement	20154-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	20154-Language certificate.pdf
Peer-review Report	20154-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	20154-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	20154-Scientific misconduct check.pdf
Scientific Editor Work List	20154-Scientific editor work list.pdf