Publication Name	World Journal of Biological Chemistry
Manuscript ID	20164
Country	Romania

Received	2015-05-29 16:40
Peer-Review Started	2015-06-02 08:16
To Make the First Decision	2015-07-27 18:38
Return for Revision	2015-08-01 17:54
Revised	2015-08-12 00:54
Second Decision	2015-10-21 17:32
Accepted by Journal Editor-in-Chief	2015-10-21 21:29
Accepted by Executive Editor-in-Chief	2015-11-04 17:36
Articles in Press	2015-11-04 17:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-02-18 13:04
Publish the Manuscript Online	2016-02-25 19:30

ISSN	1949-8454 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Biochemistry & Molecular Biology
Manuscript Type	Basic Study
Article Title	High levels of homocysteine downregulate apolipoprotein E expression via nuclear factor kappa B
Manuscript Source	Invited Manuscript
All Author List	Violeta G Trusca, Adina D Mihai, Elena V Fuior, Ioana M Fenyo and Anca V Gafencu
Funding Agency and Grant Number	Funding Agency Grant Number Romanian National Authority for Scientific Research, National Research Council - Executive Agency for Higher Education, Research, Development and Innovation Funding PN-II-ID-PCE-2011-3-0591 (to Gafencu AV) Romanian Academy, and the strategic grant financed by the European Social Found within the Sectorial Operational Program Human Resources Development 2007-2013 POSDRU/159/1.5/S/133391(to Fenyo IM and Trusca VG)
Corresponding Author	Anca V Gafencu, PhD, Department of Genomics, Transcriptomics and Molecular Therapies, Institute of Cellular Biology and Pathology, “Nicolae Simionescu” of the Romanian Academy, 8, BP Hasdeu Street, 050568 Bucharest, Romania. anca.gafencu@icbp.ro
Key Words	Apolipoprotein E; Homocysteine; Nuclear factor kappa B; Gene regulation; MAPK/ERK kinase
Core Tip	This original manuscript investigates the effect of high homocysteine (Hcy) levels on apoE expression, and the signaling pathways involved in this gene re-gulation. Our novel findings show that high doses of Hcy decrease apolipoprotein E (apoE) expression. We revealed that this regulation involves nuclear factor kappa B activation, via MAPK/ERK kinase. The Hcy-mediated decrease of apoE expression in peripheral tissues may aggravate atherosclerosis, neurodegenerative diseases and renal dysfunctions. Thus, the current manuscript may be of interest for scientists working in the field of cardiovascular disease and related inflammatory disorders.
Publish Date	2016-02-25 19:30
Citation	Trusca VG, Mihai AD, Fuior EV, Fenyo IM, Gafencu AV. High levels of homocysteine downregulate apolipoprotein E expression via nuclear factor kappa B. World J Biol Chem 2016; 7(1): 178-187
URL	http://www.wjgnet.com/1949-8454/full/v7/i1/178.htm
DOI	http://dx.doi.org/10.4331/wjbc.v7.i1.178

Full Article (PDF)	WJBC-7-178.pdf
Full Article (Word)	WJBC-7-178.doc
Manuscript File	20164-Review.doc
Answering Reviewers	20164-Answering reviewers.pdf
Audio Core Tip	20164-Audio core tip.aac
Biostatistics Review Certificate	20164-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	20164-Conflict-of-interest statement.pdf
Copyright License Agreement	20164-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	20164-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	20164-Language certificate.pdf
Peer-review Report	20164-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	20164-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	20164-Scientific misconduct check.pdf
Scientific Editor Work List	20164-Scientific editor work list.pdf