Publication Name	World Journal of Hepatology
Manuscript ID	20166
Country	Italy

Received	2015-05-29 16:47
Peer-Review Started	2015-06-02 08:22
First Decision by Editorial Office Director
Return for Revision	2015-08-22 16:31
Revised	2015-09-04 20:39
Publication Fee Transferred
Second Decision by Editor	2015-11-09 10:49
Second Decision by Editor-in-Chief	2015-11-09 16:55
Final Decision by Editorial Office Director	2015-11-25 17:35
Articles in Press	2015-11-25 17:35
Edit the Manuscript by Language Editor	2015-11-28 14:47
Typeset the Manuscript	2015-12-02 16:39
Publish the Manuscript Online	2015-12-10 15:03

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Research & Experimental Medicine
Manuscript Type	Retrospective Study
Article Title	PAI-1 4G-4G and MTHFR 677TT in non-hepatitis C virus/hepatitis B virus-related liver cirrhosis
Manuscript Source	Invited Manuscript
All Author List	Linda Pasta and Francesca Pasta
Funding Agency and Grant Number
Corresponding Author	Linda Pasta, MD, Department of Medicine, Clinica Candela, Via Villareale 54, 90141 Palermo, Italy. lindpas@yahoo.it
Key Words	PAI-1 4G-4G; MTHFR 677TT; V Leiden 506Q; Prothrombin 20210A; Liver cirrhosis; Portal vein thrombosis; Budd Chiari syndrome; Fibrogenesis
Core Tip	This study on thrombophilia in 1079 patients with liver cirrhosis showed that PAI-1 4G-4G and MTHFR C677TT were statistically more frequent in 350 patients with no viral liver cirrhosis vs 729 patients with viral liver cirrhosis. In the same patients, PAI-1 and MTHFR 677 genotypes deviated from that expected from a population in the Hardy-Weinberg equilibrium. PAI-1 4G-4G and MTHFR 677TT could be considered as factors increasing the inflammation response mecha-nisms, causing fibrogenesis and augmented intrahepatic vascular resistance, typical of liver cirrhosis. New drug therapies based on the attenuation of these mechanisms could be very easily evaluated in these patients.
Publish Date	2015-12-10 15:03
Citation	Pasta L, Pasta F. PAI-1 4G-4G and MTHFR 677TT in non-hepatitis C virus/hepatitis B virus-related liver cirrhosis. World J Hepatol 2015; 7(29): 2920-2926
URL	http://www.wjgnet.com/1948-5182/full/v7/i29/2920.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i29.2920

Full Article (PDF)	WJH-7-2920.pdf
Full Article (Word)	WJH-7-2920.doc
Manuscript File	20166-Review.docx
Answering Reviewers	20166-Answering reviewers.pdf
Audio Core Tip	20166-Audio core tip.m4a
Biostatistics Review Certificate	20166-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	20166-Conflict-of-interest statement.pdf
Copyright License Agreement	20166-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	20166-Institutional review board statement.pdf
Peer-review Report	20166-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	20166-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	20166-Scientific misconduct check.pdf
Scientific Editor Work List	20166-Scientific editor work list.pdf