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12/10/2015 3:04:00 PM | Browse: 525 | Download: 803
Publication Name World Journal of Hepatology
Manuscript ID 20166
Country/Territory Italy
Received
2015-05-29 16:47
Peer-Review Started
2015-06-02 08:22
To Make the First Decision
2015-08-14 15:27
Return for Revision
2015-08-22 16:31
Revised
2015-09-04 20:39
Second Decision
2015-11-09 10:49
Accepted by Journal Editor-in-Chief
2015-11-09 16:55
Accepted by Company Editor-in-Chief
2015-11-25 17:35
Articles in Press
2015-11-25 17:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
2015-11-28 14:47
Typeset the Manuscript
2015-12-02 16:39
Publish the Manuscript Online
2015-12-10 15:03
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Research and Experimental Medicine
Manuscript Type Retrospective Study
Article Title PAI-1 4G-4G and MTHFR 677TT in non-hepatitis C virus/hepatitis B virus-related liver cirrhosis
Manuscript Source Invited Manuscript
All Author List Linda Pasta and Francesca Pasta
Funding Agency and Grant Number
Corresponding Author Linda Pasta, MD, Department of Medicine, Clinica Candela, Via Villareale 54, 90141 Palermo, Italy. lindpas@yahoo.it
Key Words PAI-1 4G-4G; MTHFR 677TT; V Leiden 506Q; Prothrombin 20210A; Liver cirrhosis; Portal vein thrombosis; Budd Chiari syndrome; Fibrogenesis
Core Tip This study on thrombophilia in 1079 patients with liver cirrhosis showed that PAI-1 4G-4G and MTHFR C677TT were statistically more frequent in 350 patients with no viral liver cirrhosis vs 729 patients with viral liver cirrhosis. In the same patients, PAI-1 and MTHFR 677 genotypes deviated from that expected from a population in the Hardy-Weinberg equilibrium. PAI-1 4G-4G and MTHFR 677TT could be considered as factors increasing the inflammation response mecha-nisms, causing fibrogenesis and augmented intrahepatic vascular resistance, typical of liver cirrhosis. New drug therapies based on the attenuation of these mechanisms could be very easily evaluated in these patients.
Publish Date 2015-12-10 15:03
Citation Pasta L, Pasta F. PAI-1 4G-4G and MTHFR 677TT in non-hepatitis C virus/hepatitis B virus-related liver cirrhosis. World J Hepatol 2015; 7(29): 2920-2926
Url http://www.wjgnet.com/1948-5182/full/v7/i29/2920.htm
DOI http://dx.doi.org/10.4254/wjh.v7.i29.2920
Full Article (PDF) WJH-7-2920.pdf
Full Article (Word) WJH-7-2920.doc
Manuscript File 20166-Review.docx
Answering Reviewers 20166-Answering reviewers.pdf
Audio Core Tip 20166-Audio core tip.m4a
Biostatistics Review Certificate 20166-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 20166-Conflict-of-interest statement.pdf
Copyright License Agreement 20166-Copyright assignment.pdf
Data Sharing Statement 20166-Data sharing statement.pdf
Institutional Review Board Approval Form or Document 20166-Institutional review board statement.pdf
Peer-review Report 20166-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 20166-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 20166-Scientific misconduct check.pdf
Scientific Editor Work List 20166-Scientific editor work list.pdf