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9/9/2015 2:44:00 PM | Browse: 798 | Download: 799
Publication Name World Journal of Hepatology
Manuscript ID 20169
Country/Territory Belgium
Received
2015-05-29 16:52
Peer-Review Started
2015-06-02 08:35
To Make the First Decision
2015-06-18 15:11
Return for Revision
2015-06-25 17:06
Revised
2015-07-08 22:50
Second Decision
2015-07-21 19:26
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-07-27 16:49
Articles in Press
2015-07-27 16:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-08-10 14:11
Publish the Manuscript Online
2015-09-09 14:44
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Editorial
Article Title Targeting Kupffer cells in non-alcoholic fatty liver disease/non-alcoholic steatohepatitis: Why and how?
Manuscript Source Invited Manuscript
All Author List Nicolas Lanthier
Funding Agency and Grant Number
Funding Agency Grant Number
Fund for Scientific Medical Research (Belgium) FRS-FNRS CDR J.0100.15
Corresponding author Dr. Nicolas Lanthier, MD, PhD, Service d’Hépatogastroentérologie, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Avenue Hippocrate, 10, 1200 Brussels, Belgium. nicolas.lanthier@uclouvain.be
Key Words Steatosis; Non-alcoholic steatohepatitis; Insulin; Non-alcoholic fatty liver disease; Macrophage
Core Tip Previous findings in the context of obesity have pointed to the role of macrophages from the adipose tissue in the development of a chronic inflammatory status inducing insulin resistance and non-alcoholic fatty liver disease (NAFLD). However, nowadays, the activation of liver macrophages called Kupffer cells (KC) and the recruitment of monocytes have been identified as key elements for disease initiation and progression towards steatohepatitis and cirrhosis. What are the possible reasons for this deleterious KC activation in NAFLD? Are our current therapeutic approaches in NAFLD targeting KC and how? Those two important questions are raised in this paper, supported by recent studies in the field.
Publish Date 2015-09-09 14:44
Citation Lanthier N. Targeting Kupffer cells in non-alcoholic fatty liver disease/non-alcoholic steatohepatitis: Why and how? World J Hepatol 2015; 7(19): 2184-2188
Url http://www.wjgnet.com/1948-5182/full/v7/i19/2184.htm
DOI http://dx.doi.org/10.4254/wjh.v7.i19.2184
Full Article (PDF) WJH-7-2184.pdf
Full Article (Word) WJH-7-2184.doc
Manuscript File 20169-Review.docx
Answering Reviewers 20169-Answering reviewers.pdf
Audio Core Tip 20169-Audio core tip.wav
Conflict-of-Interest Disclosure Form 20169-Conflict-of-interest statement.pdf
Copyright License Agreement 20169-Copyright assignment.pdf
Peer-review Report 20169-Peer-review(s).pdf
Scientific Misconduct Check 20169-Scientific misconduct check.pdf
Scientific Editor Work List 20169-Scientific editor work list.pdf