Publication Name	World Journal of Hepatology
Manuscript ID	20169
Country	Belgium

Received	2015-05-29 16:52
Peer-Review Started	2015-06-02 08:35
To Make the First Decision	2015-06-18 15:11
Return for Revision	2015-06-25 17:06
Revised	2015-07-08 22:50
Second Decision	2015-07-21 19:26
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-07-27 16:49
Articles in Press	2015-07-27 16:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-08-10 14:11
Publish the Manuscript Online	2015-09-09 14:44

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Targeting Kupffer cells in non-alcoholic fatty liver disease/non-alcoholic steatohepatitis: Why and how?
Manuscript Source	Invited Manuscript
All Author List	Nicolas Lanthier
Funding Agency and Grant Number	Funding Agency Grant Number Fund for Scientific Medical Research (Belgium) FRS-FNRS CDR J.0100.15
Corresponding Author	Dr. Nicolas Lanthier, MD, PhD, Service d’Hépatogastroentérologie, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Avenue Hippocrate, 10, 1200 Brussels, Belgium. nicolas.lanthier@uclouvain.be
Key Words	Steatosis; Non-alcoholic steatohepatitis; Insulin; Non-alcoholic fatty liver disease; Macrophage
Core Tip	Previous findings in the context of obesity have pointed to the role of macrophages from the adipose tissue in the development of a chronic inflammatory status inducing insulin resistance and non-alcoholic fatty liver disease (NAFLD). However, nowadays, the activation of liver macrophages called Kupffer cells (KC) and the recruitment of monocytes have been identified as key elements for disease initiation and progression towards steatohepatitis and cirrhosis. What are the possible reasons for this deleterious KC activation in NAFLD? Are our current therapeutic approaches in NAFLD targeting KC and how? Those two important questions are raised in this paper, supported by recent studies in the field.
Publish Date	2015-09-09 14:44
Citation	Lanthier N. Targeting Kupffer cells in non-alcoholic fatty liver disease/non-alcoholic steatohepatitis: Why and how? World J Hepatol 2015; 7(19): 2184-2188
URL	http://www.wjgnet.com/1948-5182/full/v7/i19/2184.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i19.2184

Full Article (PDF)	WJH-7-2184.pdf
Full Article (Word)	WJH-7-2184.doc
Manuscript File	20169-Review.docx
Answering Reviewers	20169-Answering reviewers.pdf
Audio Core Tip	20169-Audio core tip.wav
Conflict-of-Interest Disclosure Form	20169-Conflict-of-interest statement.pdf
Copyright License Agreement	20169-Copyright assignment.pdf
Peer-review Report	20169-Peer-review(s).pdf
Scientific Misconduct Check	20169-Scientific misconduct check.pdf
Scientific Editor Work List	20169-Scientific editor work list.pdf