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Articles Published Processes
12/8/2015 4:45:00 PM | Browse: 1295 | Download: 2397
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Received |
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2015-05-29 20:21 |
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Peer-Review Started |
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2015-06-01 10:55 |
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To Make the First Decision |
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2015-07-27 15:50 |
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Return for Revision |
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2015-08-04 11:39 |
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Revised |
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2015-09-10 04:54 |
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Second Decision |
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2015-10-08 12:21 |
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Accepted by Journal Editor-in-Chief |
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2015-10-08 18:44 |
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Accepted by Executive Editor-in-Chief |
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2015-10-19 15:27 |
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Articles in Press |
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2015-10-19 15:27 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-12-04 10:03 |
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Publish the Manuscript Online |
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2015-12-08 16:45 |
| ISSN |
2220-3192 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Rheumatology |
| Manuscript Type |
Review |
| Article Title |
Role of mitogen- and stress-activated kinases in inflammatory arthritis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Sylvain G Bourgoin and Weili Hui |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Arthritis Society of Canada |
RG10/011(to Bourgoin SG) |
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| Corresponding Author |
Sylvain G Bourgoin, PhD, Division of Infectious Disease and Immunity, CHU de Québec Research Center and Department of Microbiology-Infectious Disease and Immunology, Faculty of Medicine, Laval University, 2705 Boul Laurier, Québec G1V 4G2, Canada. sylvain.bourgoin@crchudequebec.ulaval.ca |
| Key Words |
Lysophosphatidic acid; Mitogen activated protein kinase; Chemokines; Cytokines; Mitogen- and stress-activated kinases; Inflammation; cAMP response element-binding protein; Arthritis |
| Core Tip |
Extracellular signal-regulated kinases 1/2 and p38 mitogen activated protein kinase cascades are activated in response to stimulation with inflammatory stimuli, including lysophosphatidic acid, and are able to activate mitogen- and stress-activated kinase (MSK) 1 and MSK2 in human synovial fibroblasts. MSKs then phosphorylate the transcription factor cAMP response element-binding protein (CREB), leading to the production of pro-inflammatory and anti-inflammatory cytokines. In addition to CREB, many other downstream effectors of MSK1/2 such as nuclear factor-kappa B, histone H3, the E3 ubiquitin ligase, Tripartite motif containing 7 and high mobility group nucleosome binding domain 1 have been reported and suggested to play important functions in immunity and disease states, including arthritis. |
| Publish Date |
2015-12-08 16:45 |
| Citation |
Bourgoin SG, Hui W. Role of mitogen- and stress-activated kinases in inflammatory arthritis. World J Pharmacol 2015; 4(4): 265-273 |
| URL |
http://www.wjgnet.com/2220-3192/full/v4/i4/265.htm |
| DOI |
http://dx.doi.org/10.5497/wjp.v4.i4.265 |
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