Publication Name	World Journal of Obstetrics and Gynecology
Manuscript ID	20213
Country	United Kingdom

Received	2015-05-29 21:05
Peer-Review Started	2015-06-03 09:08
To Make the First Decision	2015-07-27 15:51
Return for Revision	2015-08-04 11:54
Revised	2015-09-03 00:00
Second Decision	2015-09-21 17:36
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-10-08 18:15
Articles in Press	2015-10-08 18:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-29 14:16
Publish the Manuscript Online	2015-11-10 08:36

ISSN	2218-6220 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Obstetrics & Gynecology
Manuscript Type	Minireviews
Article Title	Preeclampsia - What is to blame? The placenta, maternal cardiovascular system or both?
Manuscript Source	Invited Manuscript
All Author List	Dimuthu Vinayagam, Karin Leslie, Asma Khalil and Baskaran Thilaganathan
Funding Agency and Grant Number
Corresponding Author	Baskaran Thilaganathan, MD, PhD, FRCOG, Professor of Fetal Medicine, Fetal Maternal Medicine Unit, Lanesborough Wing, St George’s Hospital, Tooting, London SW17 0QT, United Kingdom. basky@pobox.com
Key Words	Preeclampsia; Placenta; Maternal cardiac function; Cardiovascular; Aetiology
Core Tip	The conventional paradigm is that preec?lampsia (PE) is solely due to placental dysfunction. However not all cases of placental dysfunction result in the syndrome of PE. Equally, placental dysfunction - as evidenced by impaired uterine artery Doppler indices, low birth weight and abnormal histology - is not always present in PE. Therefore, the heterogeneity observed in PE cannot be solely explained by placental dysfunction. There is now strong evidence supporting the role of the maternal cardiovascular system in PE. In this mini-review, we evaluate the evidence supporting a dual aetiology of PE, involving both the placenta and the maternal cardiovascular system.
Publish Date	2015-11-10 08:36
Citation	Vinayagam D, Leslie K, Khalil A, Thilaganathan B. Preeclampsia - What is to blame? The placenta, maternal cardiovascular system or both? World J Obstet Gynecol 2015; 4(4): 77-85
URL	http://www.wjgnet.com/2218-6220/full/v4/i4/77.htm
DOI	http://dx.doi.org/10.5317/wjog.v4.i4.77

Full Article (PDF)	WJOG-4-77.pdf
Full Article (Word)	WJOG-4-77.doc
Manuscript File	20213-Review.docx
Answering Reviewers	20213-Answering reviewers.pdf
Audio Core Tip	20213-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	20213-Conflict-of-interest statement.pdf
Copyright License Agreement	20213-Copyright assignment.pdf
Peer-review Report	20213-Peer-review(s).pdf
Scientific Misconduct Check	20213-Scientific misconduct check.pdf
Scientific Editor Work List	20213-Scientific editor work list.pdf