Publication Name	World Journal of Orthopedics
Manuscript ID	20220
Country	United States

Received	2015-05-30 12:02
Peer-Review Started	2015-06-01 15:36
To Make the First Decision	2015-07-28 10:42
Return for Revision	2015-08-07 18:41
Revised	2015-08-12 02:27
Second Decision	2015-08-13 17:58
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-08-21 16:35
Articles in Press	2015-08-21 16:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-02 19:53
Publish the Manuscript Online	2015-10-20 16:02

ISSN	2218-5836 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Orthopedics
Manuscript Type	Editorial
Article Title	Recent advances and future directions in the management of knee osteoarthritis: Can biological joint reconstruction replace joint arthroplasty and when?
Manuscript Source	Invited Manuscript
All Author List	Nikolaos K Paschos
Funding Agency and Grant Number
Corresponding Author	Nikolaos K Paschos, MD, PhD, Depart­ment of Biomedical Engineering, University of California, One shields ave, Davis, CA 95616, United States. npaschos@ucdavis.edu
Key Words	Osteoarthritis; Biological joint reconstruction; Total joint arthroplasty; Cartilage; Evidence-based
Core Tip	In the quest for answers for the future of joint reconstruction, this article explores how feasible is to claim today that biological joint reconstruction will soon replace artificial joint arthroplasty. Will stem cell-based therapies, biologic factors, tissue engineering and regenerative medicine be able to change orthopedic practice in the near future? What is the current evidence? On the other hand, are kinematically aligned total knee replacement, and robotic-assisted surgery able to further advance joint replacement? Based on the current evidence, some thoughts on a realistic approach for the future of joint reconstruction, biological or not, are discussed.
Publish Date	2015-10-20 16:02
Citation	Paschos NK. Recent advances and future directions in the management of knee osteoarthritis: Can biological joint recon­struction replace joint arthroplasty and when? World J Orthop 2015; 6(9): 655-659
URL	http://www.wjgnet.com/2218-5836/full/v6/i9/655.htm
DOI	http://dx.doi.org/10.5312/wjo.v6.i9.655

Full Article (PDF)	WJO-6-655.pdf
Full Article (Word)	WJO-6-655.doc
Manuscript File	20220-Review.docx
Answering Reviewers	20220-Answering reviewers.pdf
Audio Core Tip	20220-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20220-Conflict-of-interest statement.pdf
Copyright License Agreement	20220-Copyright assignment.pdf
Peer-review Report	20220-Peer-review(s).pdf
Scientific Misconduct Check	20220-Scientific misconduct check.pdf
Scientific Editor Work List	20220-Scientific editor work list.pdf