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1/15/2016 3:02:00 PM | Browse: 515 | Download: 559
Publication Name World Journal of Gastroenterology
Manuscript ID 20229
Country of Manuscript Source Italy
Received
2015-05-30 12:20
Peer-Review Started
2015-06-04 08:14
To Make the First Decision
2015-07-14 11:50
Return for Revision
2015-07-27 19:06
Revised
2015-09-03 17:25
Second Decision
2015-11-03 09:05
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-11-19 16:36
Articles in Press
2015-11-19 16:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-12-28 12:27
Publish the Manuscript Online
2016-01-15 14:54
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Pharmacology and Pharmacy
Manuscript type Review
Article Title Pharmacokinetic drug interactions in liver disease: An update
Manuscript Source Invited Manuscript
All Author List Pietro Palatini and Sara De Martin
Funding Agency and Grant Number
Corresponding author Pietro Palatini, PhD, Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Largo E. Meneghetti 2, 35131 Padova, Italy. pietro.palatini@unipd.it
Keywords Pharmacokinetic interactions; Enzyme inhibition; Enzyme induction; Liver disease; Plasma protein binding
Core Tip The widespread use of polypharmacotherapy makes drug-drug interactions due to inhibition or induction of drug-metabolizing enzymes virtually unavoidable, with consequently high risk of serious or even life-threatening adverse effects. An appropriate management of such interactions by dose adjustment is made difficult by their high interindividual variability. This review, which focuses on the variability associated with liver functional status, presents an updated discussion of the relevant literature, analyzes the mechanisms responsible for the effect of liver dys-function on the magnitude of these interactions, and outlines the criteria on which their clinical management should be based.
Publish Date 2016-01-15 14:54
Citation Palatini P, De Martin S. Pharmacokinetic drug interactions in liver disease: An update. World J Gastroenterol 2016; 22(3): 1260-1278
Url http://www.wjgnet.com/1007-9327/full/v22/i3/1260.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i3.1260
Full Article (PDF) WJG-22-1260.pdf
Full Article (Word) WJG-22-1260.doc
Manuscript File 20229-Review.docx
Answering Reviewers 20229-Answering reviewers.pdf
Audio Core Tip 20229-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 20229-Conflict-of-interest statement.pdf
Copyright License Agreement 20229-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 20229-Language certificate.pdf
Peer-review Report 20229-Peer-review(s).pdf
Scientific Misconduct Check 20229-Scientific misconduct check.pdf
Scientific Editor Work List 20229-Scientific editor work list.pdf