| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Interleukin 28B-related polymorphisms: A pathway for understanding hepatitis C virus infection?
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Raquel Francine Liermann Garcia, Simone Moreira, Ana Lucia de Araújo Ramos, Leslie Ecker Ferreira, Angelo Alves de Mattos, Cristiane Valle Tovo, Lysandro Alsina Nader, Juliene Antonio Ramos, Edson Rondinelli, Arnaldo de Jesus Dominici, Christian Evangelista Garcia, Mauro de Souza Leite Pinho, Carlos Eduardo Brandão-Mello, Cristiane Alves Villela-Nogueira and Paulo Henrique Condeixa de França |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Research Fund from University of Region of Joinville |
FAP-UNIVILLE |
|
| Corresponding Author |
Raquel Francine Liermann Garcia, MD, Departamento de Medicina, Universidade da Região de Joinville/Univille, Rua Paulo Malschitzki, 10, Campus Universitário-Zona Industrial, Joinville, 89219-719 Santa Catarina, Brazil. drargarcia@terra.com.br |
| Key Words |
Hepatitis C; Interleukin 28B; Single nucleotide polymorphisms; Sustained virological response; Brazil |
| Core Tip |
This study investigated the differential distribution of interleukin 28B genetic variants between patients with chronic hepatitis C genotype 1 infection and non-infected healthy controls, and evaluated the association of these polymorphisms with patient response to standard antiviral therapeutic regimens. Genotype and allele frequencies of rs12979860 and rs8099917 were significantly different between the patients and controls, and the patterns suggested a potential protective role against hepatitis C virus infection. Finally, the rs12979860 CC genotype showed correlation to achievement of sustained virological response following pegylated-interferon/ribavirin-based therapy. |
| Publish Date |
2013-11-18 10:59 |
| Citation |
Garcia RFL, Moreira S, Ramos ALA, Ferreira LE, Mattos AA, Tovo CV, Nader LA, Ramos JA, Rondinelli E, Dominici AJ, Garcia CE, Pinho MSL, Brand?o-Mello CE, Villela-Nogueira CA, Fran?a PHC. Interleukin 28B-related polymorphisms: A pathway for understanding hepatitis C virus infection? World J Gastroenterol 2013; 19(42): 7399-7404 |
| URL |
http://www.wjgnet.com/1007-9327/full/v19/i42/7399.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v19.i42.7399 |
