Publication Name	World Journal of Nephrology
Manuscript ID	20233
Country	India

Received	2015-05-30 12:27
Peer-Review Started	2015-05-30 17:35
To Make the First Decision	2015-06-18 15:09
Return for Revision	2015-06-30 16:52
Revised	2015-07-19 14:29
Second Decision	2015-10-08 13:29
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-10-19 15:11
Articles in Press	2015-10-19 15:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-27 11:29
Publish the Manuscript Online	2015-11-12 11:30

ISSN	2220-6124 (online)
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Category	Urology & Nephrology
Manuscript Type	Editorial
Article Title	Changing picture of renal cortical necrosis in acute kidney injury in developing country
Manuscript Source	Invited Manuscript
All Author List	Jai Prakash and Vijay Pratap Singh
Funding Agency and Grant Number
Corresponding Author	Dr. Jai Prakash, MD, FRCP, Professor and Head, Department of Nephrology, Institute of Medical Sciences, Banaras Hindu University, Pandit Madan Mohan Malviya Rd, Varanasi 221005, Uttar Pradesh, India. jprakash53@gmail.com
Key Words	Acute kidney injury; Hemolytic uremic synd­rome; Renal cortical necrosis; Postpartum hemorrhage; Septic abortion; Puerperal sepsis; Eclampsia
Core Tip	Acute kidney injury (AKI) due to renal cortical necrosis (RCN) is rare in developed countries with reported incidence of less than 2% of all cases of acute renal failure. In contrast, its incidence is higher in developing countries ranging between 6%-7% of all causes of acute renal failure (ARF). Pregnancy related complications are the most common cause of RCN. With improved health care, wider availability of dialysis, and marked decline in septic abortion, the incidence and severity of RCN has decreased in developing countries in recent years. RCN accounts for 3% of all causes of AKI in our recent study. The current incidence of RCN in obstetrical AKI was 1.44% in 2003-2014. The most common cause of RCN is haemolytic uremic syndrome among non-obstetric patients and puerperal sepsis is the leading cause of RCN in pregnant patients. The strategy involving prevention and effective management of haemorrhagic and septic complications of pregnancy will further reduce the RCN incidence in pregnant patients in developing countries.
Publish Date	2015-11-12 11:30
Citation	Prakash J, Singh VP. Changing picture of renal cortical necrosis in acute kidney injury in developing country. World J Nephrol 2015; 4(5): 480-486
URL	http://www.wjgnet.com/2220-6124/full/v4/i5/480.htm
DOI	http://dx.doi.org/10.5527/wjn.v4.i5.480

Full Article (PDF)	WJN-4-480.pdf
Full Article (Word)	WJN-4-480.doc
Manuscript File	20233-Review.docx
Answering Reviewers	20233-Answering reviewers.pdf
Audio Core Tip	20233-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20233-Conflict-of-interest statement.pdf
Copyright License Agreement	20233-Copyright assignment.pdf
Peer-review Report	20233-Peer-review(s).pdf
Scientific Misconduct Check	20233-Scientific misconduct check.pdf
Scientific Editor Work List	20233-Scientific editor work list.pdf