Publication Name	World Journal of Gastroenterology
Manuscript ID	20235
Country	Taiwan

Received	2015-05-30 12:26
Peer-Review Started	2015-06-04 08:50
To Make the First Decision	2015-07-14 11:50
Return for Revision	2015-07-27 19:10
Revised	2015-08-14 13:09
Second Decision	2015-10-14 09:03
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-10-26 17:52
Articles in Press	2015-10-26 17:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-05 19:38
Publish the Manuscript Online	2016-01-20 16:55

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Metabolic alterations and hepatitis C: From bench to bedside
Manuscript Source	Invited Manuscript
All Author List	Ming-Ling Chang
Funding Agency and Grant Number	Funding Agency Grant Number Chang Gung Medical Research Program CMRPG380353 Chang Gung Medical Research Program CMRPG3B1251 Chang Gung Medical Research Program CMRPG3B0401 Chang Gung Medical Research Program CMRPG3B1741 Chang Gung Medical Research Program CMRPG3B1742 Chang Gung Medical Research Program XMRPG3A0521 National Science Council, Taiwan 100-2314-B-182-069- National Science Council, Taiwan 101-2314-B-182-083- National Science Council, Taiwan 102-2628-B-182-021-MY3
Corresponding Author	Ming-Ling Chang, MD, PhD, Liver Research Center, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, No. 5, Fu Hsing Street, Kuei Shan, Taoyuan 33305, Taiwan. mlchang8210@gmail.com
Key Words	Lipid; Glucose; Cardiovascular; Hepatitis C virus; Core; Nonstructural protein 5 A; Transgenic mice
Core Tip	Hepatitis C virus (HCV) is thought to cause hypolipidemia, hepatic steatosis, insulin resistance, and diabetes. Its life cycle depends on host cholesterol metabolism. HCV core protein and nonstructural protein 5A perturb crucial metabolic pathways. Many cross-sectional studies have demonstrated increased cardiometabolic risks in HCV patients. Utilizing anti-HCV therapy, most cohort studies have demonstrated the favorable effects of HCV clearance in attenuating cardiometabolic risks. Adipose tissue is an important endocrine organ due to its release of adipocytokines, which strongly regulate metabolism. A comprehensive overview of HCV-associated metabolic and adipocyto-kine alterations, from bench to bedside, is presented in this topic highlight.
Publish Date	2016-01-20 16:55
Citation	Chang ML. Metabolic alterations and hepatitis C: From bench to bedside. World J Gastroenterol 2016; 22(4): 1461-1476
URL	http://www.wjgnet.com/1007-9327/full/v22/i4/1461.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i4.1461

Full Article (PDF)	WJG-22-1461.pdf
Full Article (Word)	WJG-22-1461.doc
Manuscript File	20235-Review.doc
Answering Reviewers	20235-Answering reviewers.pdf
Audio Core Tip	20235-Audio core tip.mp3
Copyright License Agreement	20235-Copyright assignment.pdf
Peer-review Report	20235-Peer-review(s).pdf
Scientific Misconduct Check	20235-Scientific misconduct check.pdf
Scientific Editor Work List	20235-Scientific editor work list.pdf