Publication Name	World Journal of Biological Chemistry
Manuscript ID	20242
Country	United States

Received	2015-05-30 12:43
Peer-Review Started	2015-05-30 16:54
To Make the First Decision	2015-06-18 15:08
Return for Revision	2015-06-30 16:59
Revised	2015-07-29 11:37
Second Decision	2015-09-21 17:48
Accepted by Journal Editor-in-Chief	2015-09-21 18:07
Accepted by Executive Editor-in-Chief	2015-09-30 18:46
Articles in Press	2015-09-30 18:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-03 07:24
Publish the Manuscript Online	2015-11-23 10:19

ISSN	1949-8454 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Biochemistry & Molecular Biology
Manuscript Type	Basic Study
Article Title	Connective tissue growth factor differentially binds to members of the cystine knot superfamily and potentiates platelet-derived growth factor-B signaling in rabbit corneal fibroblast cells
Manuscript Source	Invited Manuscript
All Author List	Liya Pi, Pei-Yu Chung, Sriniwas Sriram, Masmudur M Rahman, Wen-Yuan Song, Edward W Scott, Bryon E Petersen and Gregory S Schultz
Funding Agency and Grant Number	Funding Agency Grant Number NIH RO1 DK058614 NIH RO1 DK065096(to BEP) NIH RO1 EY05587(to GSS) Chris DiMarco Institutional Research Grant from American Cancer Society award to LP
Corresponding Author	Liya Pi, PhD, Research Assistant Professor, Department of Pediatrics, University of Florida, Gainesville, FL 32610, United States. lpi@peds.ufl.edu
Key Words	Connective tissue growth factor; Vascular endothelial growth factor A; Platelet derived growth factor B; Transforming growth factor-; Bone morphogenetic protein-4; Yeast two-hybrid analysis; Surface plasma resonance; Rabbit corneal fibroblast cells; Platelet-derived growth factor receptor; Platelet-derived growth factor-B signaling
Core Tip	The relative binding strength of connective tissue growth factor (CTGF) was vascular endothelial growth factor-A > bone morphogenetic protein-4 > transforming growth factor-?1 > platelet-derived growth factor (PDGF)-B. CTGF binding could potentiate PDGF-B signaling as evidenced by enhanced phosphorylation of PDGF receptor ? and downstream AKT molecules in rabbit corneal fibroblast cells. Our findings provide deep insight into CTGF action in fine-tuned regulation of extracellular signaling mediated by different cysteine knot containing growth factors.
Publish Date	2015-11-23 10:19
Citation	Pi L, Chung PY, Sriram S, Rahman MM, Song WY, Scott EW, Petersen BE, Schultz GS. Connective tissue growth factor differentially binds to members of the cystine knot superfamily and potentiates platelet-derived growth factor-B signaling in rabbit corneal fibroblast cells. World J Biol Chem 2015; 6(4): 379-388
URL	http://www.wjgnet.com/1949-8454/full/v6/i4/379.htm
DOI	http://dx.doi.org/10.4331/wjbc.v6.i4.379

Full Article (PDF)	WJBC-6-379.pdf
Full Article (Word)	WJBC-6-379.doc
Manuscript File	20242-Review.docx
Answering Reviewers	20242-Answering reviewers.pdf
Audio Core Tip	20242-Audio core tip.mp3
Biostatistics Review Certificate	20242-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	20242-Conflict-of-interest statement.pdf
Copyright License Agreement	20242-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	20242-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	20242-Institutional review board statement.pdf
Peer-review Report	20242-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	20242-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	20242-Scientific misconduct check.pdf
Scientific Editor Work List	20242-Scientific editor work list.pdf