Publication Name	World Journal of Hepatology
Manuscript ID	20262
Country	Japan

Received	2015-06-01 09:21
Peer-Review Started	2015-06-01 14:39
First Decision by Editorial Office Director
Return for Revision	2015-07-11 15:26
Revised	2015-07-18 14:54
Publication Fee Transferred
Second Decision by Editor	2015-11-04 18:04
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2015-11-17 08:34
Articles in Press	2015-11-17 08:34
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-23 12:22
Publish the Manuscript Online	2015-11-27 17:14

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Alpha-fetoprotein and des-gamma-carboxy-prothrombin at twenty-four weeks after interferon-based therapy predict hepatocellular carcinoma development
Manuscript Source	Invited Manuscript
All Author List	Satoshi Shakado, Shotaro Sakisaka, Kazuaki Chayama, Takeshi Okanoue, Joji Toyoda, Namiki Izumi, Akihiro Matsumoto, Tetsuo Takehara, Akio Ido, Yoichi Hiasa, Kentaro Yoshioka, Hideyuki Nomura, Yoshiyuki Ueno, Masataka Seike and Hiromitsu Kumada
Funding Agency and Grant Number	Funding Agency Grant Number Japanese Ministry of Health, Welfare and Labour
Corresponding Author	Satoshi Shakado, MD, Associate Professor, Department of Gastroenterology and Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka City, Fukuoka 814-0180, Japan. shakado@cis.fukuoka-u.ac.jp
Key Words	Des-γ-carboxy prothrombin; Hepatocellular carcinoma; Alpha-fetoprotein; Interferon; Hepatitis C virus; Liver cirrhosis; Ribavirin
Core Tip	Interferon (IFN)-based therapy reduces the rate of hepatocellular carcinoma (HCC) development in patients with chronic hepatitis C virus (HCV) infection. However, HCC development has frequently been re-ported in HCV-related liver cirrhosis (LC-C) patients who achieved sustained virological response. We conducted a multicenter, retrospective study to evaluate the relationship between clinical factors and HCC development in Japanese LC-C patients treated with IFN and ribavirin therapy. We suggested that the elevation of Alpha-fetoprotein and des-γ-carboxy prothrombin levels at 24 wk after the completion of IFN and ribavirin therapy were strongly associated with the incidence of HCC irrespective of virological response among Japanese LC-C patients.
Publish Date	2015-11-27 17:14
Citation	Shakado S, Sakisaka S, Chayama K, Okanoue T, Toyoda J, Izumi N, Matsumoto A, Takehara T, Ido A, Hiasa Y, Yoshioka K, Nomura H, Ueno Y, Seike M, Kumada H. Alpha-fetoprotein and des-gamma-carboxy-prothrombin at twenty-four weeks after interferon-based therapy predict hepatocellular carcinoma development. World J Hepatol 2015; 7(27): 2757-2764
URL	http://www.wjgnet.com/1948-5182/full/v7/i27/2757.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i27.2757

Full Article (PDF)	WJH-7-2757.pdf
Full Article (Word)	WJH-7-2757.doc