Publication Name	World Journal of Cardiology
Manuscript ID	20300
Country	Greece

Received	2015-06-02 10:06
Peer-Review Started	2015-06-04 19:11
To Make the First Decision	2015-06-18 15:08
Return for Revision	2015-06-30 17:08
Revised	2015-07-16 15:50
Second Decision	2015-09-21 17:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-09-30 18:46
Articles in Press	2015-09-30 18:47
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-10 09:01
Publish the Manuscript Online	2015-12-24 17:39

ISSN	1949-8462 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Minireviews
Article Title	Current status of high on-treatment platelet reactivity in patients with coronary or peripheral arterial disease: Mechanisms, evaluation and clinical implications
Manuscript Source	Invited Manuscript
All Author List	Stavros Spiliopoulos and Georgios Pastromas
Funding Agency and Grant Number
Corresponding Author	Stavros Spiliopoulos, MD, PhD, EBIR, Department of Interventional Radiology, Patras University Hospital, Ippokratous Avenue, 26504 Rio, Greece. stavspiliop@upatras.gr
Key Words	Coronary disease; Clopidogrel; Aspirin; High on treatment platelet reactivity; Peripheral arterial disease; Antiplatelet therapy; Ticagrelor; Prasugrel
Core Tip	Recent data related high on-treatment platelet reactivity (HTPR) with adverse clinical outcomes, such as stent thrombosis and repeat procedures, following coronary or peripheral endovascular revascularization procedures. Notably, the incidence of patients suffering from peripheral arterial disease demonstrating inadequate response to clopidogrel is around 50%, which is much higher than the approximately 30% reported for patients suffering from coronary artery disease. Novel more potent antiplatelet P2Y12 agents seem to overcome the phenomenon of HTPR decreasing ischemic events with the cost of increased bleeding risk. Until today no major trial demonstrated clinical improvement for patients undergoing platelet function test-guided individualized antiplatelet therapy. Prescription of new antithrombotic agents aims in avoiding major cardiovascular adverse events, as well as sustaining vessel patency following revascularization. Therefore, improving antiplatelet therapy, considering the risk/benefit ratio, is imperative especially in HTPR patients. Further large-scale studies are awaited to elucidate the role of individualized therapy.
Publish Date	2015-12-24 17:39
Citation	Spiliopoulos S, Pastromas G. Current status of high on-treatment platelet reactivity in patients with coronary or peripheral arterial disease: Mechanisms, evaluation and clinical implications. World J Cardiol 2015; 7(12): 912-921
URL	http://www.wjgnet.com/1949-8462/full/v7/i12/912.htm
DOI	http://dx.doi.org/10.4330/wjc.v7.i12.912

Full Article (PDF)	WJC-7-912.pdf
Full Article (Word)	WJC-7-912.doc
Manuscript File	20300-Review.docx
Answering Reviewers	20300-Answering reviewers.pdf
Audio Core Tip	20300-Audio core tip.wma
Conflict-of-Interest Disclosure Form	20300-Conflict-of-interest statement.pdf
Copyright License Agreement	20300-Copyright assignment.pdf
Peer-review Report	20300-Peer-review(s).pdf
Scientific Misconduct Check	20300-Scientific misconduct check.pdf
Scientific Editor Work List	20300-Scientific editor work list.pdf