Publication Name	World Journal of Gastroenterology
Manuscript ID	20337
Country	Italy

Received	2015-06-02 09:40
Peer-Review Started	2015-06-03 13:11
To Make the First Decision	2015-07-13 15:22
Return for Revision	2015-07-17 16:59
Revised	2015-09-28 05:17
Second Decision	2015-12-11 15:21
Accepted by Journal Editor-in-Chief	2015-12-11 23:48
Accepted by Executive Editor-in-Chief	2015-12-21 14:05
Articles in Press	2015-12-21 14:05
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-12-29 11:34
Typeset the Manuscript	2016-01-08 14:53
Publish the Manuscript Online	2016-01-31 11:48

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Inflammation in irritable bowel syndrome: Myth or new treatment target?
Manuscript Source	Invited Manuscript
All Author List	Emanuele Sinagra, Giancarlo Pompei, Giovanni Tomasello, Francesco Cappello, Gaetano Cristian Morreale, Georgios Amvrosiadis, Francesca Rossi, Attilio Ignazio Lo Monte, Aroldo Gabriele Rizzo and Dario Raimondo
Funding Agency and Grant Number
Corresponding Author	Dr. Emanuele Sinagra, Gastroenterology and Endoscopy Unit, Fondazione Istituto San Raffaele Giglio, Contrada Pietra Pollastra Pisciotto, via Zagara Snc, Contrada Ogliastrillo, 90015 Cefalù, Italy. emanuelesinagra83@googlemail.com
Key Words	Inflammation; Irritable bowel syndrome; Mast cells; Neuroendocrine cells; Pathology
Core Tip	Low-grade intestinal inflammation plays a key role in the pathophysiology of irritable bowel syndrome, and this influence is likely multifactorial. Several evidences showed microscopic and molecular abnormalities in large subsets of patients with irritable bowel syndrome. Understanding the mechanisms underlying the low-grade inflammation in this disease may help to design clinical trials to test the efficacy and safety of drugs that target this pathophysiologic mechanism.
Publish Date	2016-01-31 11:48
Citation	Sinagra E, Pompei G, Tomasello G, Cappello F, Morreale GC, Amvrosiadis G, Rossi F, Lo Monte AI, Rizzo AG, Raimondo D. Inflammation in irritable bowel syndrome: Myth or new treatment target? World J Gastroenterol 2016; 22(7): 2242-2255
URL	http://www.wjgnet.com/1007-9327/full/v22/i7/2242.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i7.2242

Full Article (PDF)	WJG-22-2242.pdf
Full Article (Word)	WJG-22-2242.doc
Manuscript File	20337-Review.doc
Answering Reviewers	20337-Answering reviewers.pdf
Audio Core Tip	20337-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	20337-Conflict-of-interest statement.pdf
Copyright License Agreement	20337-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	20337-Language certificate.pdf
Peer-review Report	20337-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	20337-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	20337-Scientific misconduct check.pdf
Scientific Editor Work List	20337-Scientific editor work list.pdf