Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	20371
Country	United States

Received	2015-06-02 16:03
Peer-Review Started	2015-06-04 17:30
To Make the First Decision	2015-07-06 14:48
Return for Revision	2015-07-11 16:18
Revised	2015-07-16 23:16
Second Decision	2015-09-10 08:27
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-09-18 13:31
Articles in Press	2015-09-18 13:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-23 12:05
Publish the Manuscript Online	2015-11-17 12:17

ISSN	2150-5330 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Pathology
Manuscript Type	Editorial
Article Title	Role of cancer stem cells in age-related rise in colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Pratima Nangia-Makker, Yingjie Yu and Adhip PN Majumdar
Funding Agency and Grant Number	Funding Agency Grant Number National Institutes of Health AG014343 National Institutes of Health 1R21CA175916-01 Department of Veterans Affairs I101BX001927 Metropolitan Detroit Research and Education Foundation to Adhip PN Majumdar
Corresponding Author	Pratima Nangia-Makker, PhD, Veterans Affairs Medical Center, Department of Internal Medicine, Karmanos Cancer Institute, Wayne State University-School of Medicine, Research Service, 4646 John R, Room-B4238, De­troit, MI 48201, United States. makkerp@karmanos.org
Key Words	Cancer stem cells; Aging; Colorectal cancer; Colonospheres; Colonic crypt
Core Tip	Sporadic colorectal cancer (CRC), an age-related disease, occurs in 80%-85% of patients with CRC. The changes that occur at the cellular and molecular levels during ageing leading to a rise in CRC are poorly understood. We have postulated a role for cancer stem/stem-like cells that are shown to possess self-renewing, pluripotent properties. These cells, which reside at the bottom of the colonic crypt, are thought to regulate the processes of carcinogenesis. In this editorial, we have briefly described the recent work on the evolution of cancer stem cells in gastro-intestinal tract with particular reference to the colon, and how they are involved in the development and progression of CRC, the incidence of which increases with advancing age.
Publish Date	2015-11-17 12:17
Citation	Nangia-Makker P, Yu Y, Majumdar APN. Role of cancer stem cells in age-related rise in colorectal cancer. World J Gastrointest Pathophysiol 2015; 6(4): 86-89
URL	http://www.wjgnet.com/2150-5330/full/v6/i4/86.htm
DOI	http://dx.doi.org/10.4291/wjgp.v6.i4.86

Full Article (PDF)	WJGP-6-86.pdf
Full Article (Word)	WJGP-6-86.doc
Manuscript File	20371-Review.doc
Answering Reviewers	20371-Answering reviewers.pdf
Audio Core Tip	20371-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20371-Conflict-of-interest statement.pdf
Copyright License Agreement	20371-Copyright assignment.pdf
Peer-review Report	20371-Peer-review(s).pdf
Scientific Misconduct Check	20371-Scientific misconduct check.pdf
Scientific Editor Work List	20371-Scientific editor work list.pdf