Publication Name	World Journal of Clinical Cases
Manuscript ID	20390
Country

Received	2015-06-03 08:56
Peer-Review Started
First Decision by Editorial Office Director
Return for Revision
Revised
Publication Fee Transferred
Second Decision by Editor	2015-06-04 07:56
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2015-06-16 16:57
Articles in Press	2015-06-16 16:57
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-08-31 13:53
Publish the Manuscript Online	2015-09-15 18:41

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Critical Care Medicine
Manuscript Type	Basic Study
Article Title	Leukocyte function-associated antigen-1 deficiency impairs responses to polymicrobial sepsis
Manuscript Source	Invited Manuscript
All Author List	Jia-Ren Liu, Xiaohui Han, Sulpicio G Soriano and Koichi Yuki
Funding Agency and Grant Number
Corresponding Author	Koichi Yuki, MD, Department of Anes­thesiology, Perioperative and Pain Medicine, Boston Children’s Hospital, 300 Longwood Avenue, Boston, MA 02115, United States. koichi.yuki@childrens.harvard.edu
Key Words	Leukocyte function-associated antigen-1; Tissue injury; Neutrophil recruitment; Polymicrobial sepsis; Apoptosis
Core Tip	We report our result on the role of leukocyte function-associated antigen-1 (LFA-1) in polymicrobial abdominal sepsis model induced by cecal ligation and puncture. LFA-1 is a key player in neutrophil migration, but its role in neutrophil migration to tissues in poly-microbial sepsis is yet to be determined. This study demonstrated that LFA-1 deficiency blocked neutrophil migration to the abdominal cavity, but maintained migration to other organs, and reduced survival in sepsis.
Publish Date	2015-09-15 18:41
Citation	Liu JR, Han X, Soriano SG, Yuki K. Leukocyte function-associated antigen-1 deficiency impairs responses to polymicrobial sepsis. World J Clin Cases 2015; 3(9): 793-806
URL	http://www.wjgnet.com/2307-8960/full/v3/i9/793.htm
DOI	http://dx.doi.org/10.12998/wjcc.v3.i9.793

Full Article (PDF)	WJCC-3-793.pdf
Full Article (Word)	WJCC-3-793.doc
Manuscript File	20390-Review.doc
Answering Reviewers	20390-Answering reviewers.pdf
Audio Core Tip	20390-Audio core tip.mp3
Biostatistics Review Certificate	20390-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	20390-Conflict-of-interest statement.pdf
Copyright License Agreement	20390-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	20390-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	Institutional_Review_Board_Statement_20150602221641.docx
Peer-review Report	20390-Peer-review(s).pdf
Scientific Misconduct Check	20390-Scientific misconduct check.pdf
Scientific Editor Work List	20390-Scientific editor work list.pdf