Publication Name	World Journal of Gastroenterology
Manuscript ID	20405
Country	China

Received	2015-06-03 17:49
Peer-Review Started	2015-06-06 17:54
To Make the First Decision	2015-07-10 14:36
Return for Revision	2015-07-13 19:38
Revised	2015-07-24 15:39
Second Decision	2015-08-27 20:14
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-08-29 17:12
Articles in Press	2015-08-29 17:12
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-09-25 09:35
Typeset the Manuscript	2015-12-09 17:54
Publish the Manuscript Online	2015-12-24 11:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Effect of gingerol on colonic motility via inhibition of calcium channel currents in rats
Manuscript Source	Unsolicited Manuscript
All Author List	Zheng-Xu Cai, Xu-Dong Tang, Feng-Yun Wang, Zhi-Jun Duan, Yu-Chun Li, Juan-Juan Qiu and Hui-Shu Guo
Funding Agency and Grant Number	Funding Agency Grant Number National Basic Research Program of China（973 Program） 2013CB531703 National Natural Science Foundation of China 81273919 Natural Science Foundation of Liaoning Province 2012225020 Natural Science Foundation of Liaoning Province 2013023002
Corresponding Author	Hui-Shu Guo, PhD, Professor, Chief, Central Laboratory, The First Affiliated Hospital of Dalian Medical University, 222 Zhongshan Lu, Dalian 116011, Liaoning Province, China. guohuishu1@126.com
Key Words	Gingerol; Colonic motility; L-type calcium channel current; Spontaneous contraction; Longitudinal smooth muscle myocytes
Core Tip	Gingerol, a non-pungent molecule, has an inhibitory effect on colonic motility. There are many ion channels and second messengers involved in this process; however, no reports have described the effects of gingerol on L-type calcium channel currents. In the present study, we found that 6-gingerol obviously inhibited spontaneous contraction of longitudinal smooth muscle by preventing Ca2+ influx through L-type calcium channels.
Publish Date	2015-12-24 11:11
Citation	Cai ZX, Tang XD, Wang FY, Duan ZJ, Li YC, Qiu JJ, Guo HS. Effect of gingerol on colonic motility via inhibition of calcium channel currents in rats. World J Gastroenterol 2015; 21(48): 13466-13472
URL	http://www.wjgnet.com/1007-9327/full/v21/i48/13466.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i48.13466

Full Article (PDF)	WJG-21-13466.pdf
Full Article (Word)	WJG-21-13466.doc
Manuscript File	20405-Review.docx
Answering Reviewers	20405-Answering reviewers.pdf
Audio Core Tip	20405-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20405-Conflict-of-interest statement.pdf
Copyright License Agreement	20405-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	20405-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	20405-Language certificate.pdf
Peer-review Report	20405-Peer-review(s).pdf
Scientific Misconduct Check	20405-Scientific misconduct check.pdf
Scientific Editor Work List	20405-Scientific editor work list.pdf