Publication Name	World Journal of Hepatology
Manuscript ID	20437
Country	Canada

Received	2015-06-04 17:03
Peer-Review Started	2015-06-09 15:44
To Make the First Decision	2015-07-06 14:49
Return for Revision	2015-07-12 15:10
Revised	2015-07-13 12:40
Second Decision	2015-09-10 08:28
Accepted by Journal Editor-in-Chief	2015-09-11 18:57
Accepted by Company Editor-in-Chief	2015-09-18 13:33
Articles in Press	2015-09-18 13:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-16 17:16
Publish the Manuscript Online	2015-10-30 11:57

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Unusual case of drug-induced cholestasis due to glucosamine and chondroitin sulfate
Manuscript Source	Unsolicited Manuscript
All Author List	Stephen Ip, Rachel Jeong, David F Schaeffer and Eric M Yoshida
Funding Agency and Grant Number
Corresponding Author	Dr. Eric M Yoshida, Professor of Medicine, Division of Gastroenterology, Vancouver General Hospital, University of British Columbia, 5th Floor, 2775 Laurel Street, Vancouver, British Columbia V5Z 1M9, Canada. eric.yoshida@vch.ca
Key Words	Glucosamine; Chondroitin; Hepatotoxicity; Cholestasis; Jaundice
Core Tip	Glucosamine and chondroitin sulfate are common over-the-counter medications available in North America and other countries in the treatment of osteoarthritis. We report a unique case of drug-induced cholestatic injury caused by this combination tablet. The etiology of this patient’s new jaundice went undiagnosed despite extensive investigations over three months. Only after careful questioning of his medication history and review of his liver biopsy was the correct diagnosis obtained. This case adds to the increasing reports of hepatoxicity related to this supplement. Furthermore, it highlights the importance of a complete medication history, especially over-the-counter medications, in the assessment of cholestatic jaundice.
Publish Date	2015-10-30 11:57
Citation	Ip S, Jeong R, Schaeffer DF, Yoshida EM. Unusual case of drug-induced cholestasis due to glucosamine and chondroitin sulfate. World J Hepatol 2015; 7(24): 2559-2562
URL	http://www.wjgnet.com/1948-5182/full/v7/i24/2559.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i24.2559

Full Article (PDF)	WJH-7-2559.pdf
Full Article (Word)	WJH-7-2559.doc
Manuscript File	20437-Review.docx
Answering Reviewers	20437-Answering reviewers.pdf
Audio Core Tip	20437-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20437-Conflict-of-interest statement.pdf
Copyright License Agreement	20437-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20150604125900.pdf
Institutional Review Board Approval Form or Document	20437-Institutional review board statement.pdf
Peer-review Report	20437-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	20437-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	20437-Scientific misconduct check.pdf
Scientific Editor Work List	20437-Scientific editor work list.pdf