Publication Name	World Journal of Cardiology
Manuscript ID	20503
Country	Canada

Received	2015-06-08 08:30
Peer-Review Started	2015-06-10 14:30
To Make the First Decision	2015-09-16 13:52
Return for Revision	2015-09-18 15:51
Revised	2015-10-16 03:28
Second Decision	2015-11-30 09:38
Accepted by Journal Editor-in-Chief	2015-12-01 06:06
Accepted by Executive Editor-in-Chief	2015-12-11 16:14
Articles in Press	2015-12-11 16:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-02-03 09:50
Publish the Manuscript Online	2016-02-22 10:45

ISSN	1949-8462 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Review
Article Title	Genetic testing in congenital heart disease: A clinical approach
Manuscript Source	Invited Manuscript
All Author List	Marie A Chaix, Gregor Andelfinger and Paul Khairy
Funding Agency and Grant Number
Corresponding Author	Dr. Paul Khairy, Montreal Heart Institute Adult Congenital Center, Université de Montréal, 5000 Belanger St. E, Montreal, Quebec H1T 1C8, Canada. paul.khairy@umontreal.ca
Key Words	Congenital heart disease; Genetics; Genetic screening; Genetic testing
Core Tip	Monogenic models and chromosomal abnor?malities have been associated with syndromic and non-syndromic forms of congenital heart disease (CHD), paving the way for genetic investigation and testing to shoulder an important role in patient management. Herein, we present an overview of the role of genetics in CHD, propose various clinical scenarios in which genetic testing may be appropriate, and discuss practical implications with regards to when and how to order genetic tests. Summary tables are provided regarding the various genes implicated in syndromic and non-syndromic forms of CHD and recurr?ence risks in siblings and offspring.
Publish Date	2016-02-22 10:45
Citation	Chaix MA, Andelfinger G, Khairy P. Genetic testing in con¬genital heart disease: A clinical approach. World J Cardiol 2016; 8(2): 180-191
URL	http://www.wjgnet.com/1949-8462/full/v8/i2/180.htm
DOI	http://dx.doi.org/10.4330/wjc.v8.i2.180

Full Article (PDF)	WJC-8-180.pdf
Full Article (Word)	WJC-8-180.doc
Manuscript File	20503-Review.docx
Answering Reviewers	20503-Answering reviewers.pdf
Audio Core Tip	20503-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	20503-Conflict-of-interest statement.pdf
Copyright License Agreement	20503-Copyright assignment.pdf
Peer-review Report	20503-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	20503-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	20503-Scientific misconduct check.pdf
Scientific Editor Work List	20503-Scientific editor work list.pdf