Publication Name	World Journal of Gastroenterology
Manuscript ID	20511
Country	South Korea

Received	2015-06-08 15:57
Peer-Review Started	2015-06-11 09:11
First Decision by Editorial Office Director
Return for Revision	2015-07-14 18:28
Revised	2015-07-17 09:03
Publication Fee Transferred
Second Decision by Editor	2015-09-28 16:16
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2015-09-30 10:35
Articles in Press	2015-09-30 10:36
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-23 10:12
Publish the Manuscript Online	2015-12-15 12:22

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Infectious Diseases
Manuscript Type	Observational Study
Article Title	Development of Fok-I based nested polymerase chain reaction-restriction fragment length polymorphism analysis for detection of hepatitis B virus X region V5M mutation
Manuscript Source	Unsolicited Manuscript
All Author List	Hong Kim, Seok-Hyun Hong, Seoung-Ae Lee, Jeong-Ryeol Gong and Bum-Joon Kim
Funding Agency and Grant Number	Funding Agency Grant Number National Research Foundation of Korea 2013-005810
Corresponding Author	Bum-Joon Kim, Professor, Department of Biomedical Sciences, Microbiology and Immunology, and Liver Research Institute, Seoul National University College of Medicine, Seoul 110-799, South Korea. kbumjoon@snu.ac.kr
Key Words	Hepatitis B virus; X antigen; Polymerase chain reaction-restriction fragment length polymorphism analysis; V5M mutation; Hepatocellur carcinoma
Core Tip	In the present study, we developed a reliable and cost-effective Fok-I nested polymerase chain reaction-restriction fragment length polymorphism analysis (PRA) method for the detection of V5M from chronic patients with genotype C2 infection. In addition, our epidemiological data based on the Fok-I nested PRA method strongly support the previous reports that V5M may play a very pivotal role in hepato-carcinogenesis, at least in chronic patients infected with genotype C2.
Publish Date	2015-12-15 12:22
Citation	Kim H, Hong SH, Lee SA, Gong JR, Kim BJ. Development of Fok-I based nested polymerase chain reaction-restriction fragment length polymorphism analysis for detection of hepatitis B virus X region V5M mutation. World J Gastroenterol 2015; 21(47): 13360-13367
URL	http://www.wjgnet.com/1007-9327/full/v21/i47/13360.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i47.13360

Full Article (PDF)	WJG-21-13360.pdf
Full Article (Word)	WJG-21-13360.doc
Manuscript File	20511-Review.doc
Answering Reviewers	20511-Answering reviewers.doc
Audio Core Tip	20511-Audio core tip.mp3
Copyright License Agreement	20511-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	20511-Language certificate.pdf
Scientific Misconduct Check	20511-Scientific misconduct check.pdf
Scientific Editor Work List	20511-Scientific editor work list.pdf