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Articles Published Processes
2/25/2016 7:30:00 PM | Browse: 1341 | Download: 1620
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Received |
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2015-06-09 09:17 |
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Peer-Review Started |
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2015-06-11 16:18 |
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To Make the First Decision |
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2015-08-16 14:43 |
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Return for Revision |
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2015-08-25 14:51 |
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Revised |
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2015-09-22 00:17 |
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Second Decision |
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2015-10-22 15:07 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-11-04 17:16 |
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Articles in Press |
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2015-11-04 17:16 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-02-18 08:20 |
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Publish the Manuscript Online |
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2016-02-25 19:30 |
| ISSN |
1949-8454 (online) |
| Open Access |
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Review |
| Article Title |
Dynamic interplay between adhesion surfaces in carcinomas: Cell-cell and cell-matrix crosstalk
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yvonne E Smith, Sri HariKrishna Vellanki and Ann M Hopkins |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Past and present funding in the senior author’s laboratory as follows - Health Research Board of Ireland |
HRA-POR-2014-545 |
| Past and present funding in the senior author’s laboratory as follows - Health Research Board of Ireland |
HRA/2009/49 |
| Past and present funding in the senior author’s laboratory as follows - Health Research Board of Ireland |
RP/2006/95 (to Hopkins AM) |
| Science Foundation Ireland |
13/IA/1994 |
| Science Foundation Ireland |
2008/RFP/NSC1427 |
| Science Foundation Ireland |
2008/RFP/NSC1427 TIDA Feasibility 10 to Hopkins AM |
| Brazil Science Without Borders |
CAPES-13306-13-8 |
| Beaumont Hospital Cancer Research and Development Trust |
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| Corresponding Author |
Ann M Hopkins, PhD, Department of Surgery, Royal College of Surgeons in Ireland, RCSI Education and Research Centre, Smurfit Building, Beaumont Hospital, Dublin 9, Ireland. annhopkins@rcsi.ie
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| Key Words |
Cell-cell; Cell-matrix; Adhesion; Cancer; Crosstalk; Pathogens; Epithelial; Barrier function; Tight junction; Cell migration; Apical junctional complex; Adherens junction; Adhesion molecules; Extracellular matrix; Tyrosine kinases; GTPases; Rho |
| Core Tip |
Deregulation of cell-cell and cell-matrix signaling makes well-established contributions to key elements of cancer initiation and progression. In this review we discuss mechanisms of crosstalk between these spatially-distinct adhesion sites in epithelial cells, with a view to understanding their therapeutic targeting in epithelial tumors (carcinomas). A particular focus is placed upon Rho GTPases and tyrosine kinases as mediators of inter-junctional crosstalk, in addition to the concept of opportunistic pathogenic infection as a paradigm for inter-junctional crosstalk. Overall, this review posits that a greater understanding of cell-cell and cell-matrix adhesion crosstalk will drive novel aspects of cancer drug discovery.
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| Publish Date |
2016-02-25 19:30 |
| Citation |
Smith YE, Vellanki SH, Hopkins AM. Dynamic interplay between adhesion surfaces in carcinomas: Cell-cell and cell-matrix crosstalk. World J Biol Chem 2016; 7(1): 64-77 |
| URL |
http://www.wjgnet.com/1949-8454/full/v7/i1/64.htm |
| DOI |
http://dx.doi.org/10.4331/wjbc.v7.i1.64 |
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