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2/25/2016 7:30:00 PM | Browse: 538 | Download: 556
Publication Name World Journal of Biological Chemistry
Manuscript ID 20525
Country/Territory Ireland
Received
2015-06-09 09:17
Peer-Review Started
2015-06-11 16:18
To Make the First Decision
2015-08-16 14:43
Return for Revision
2015-08-25 14:51
Revised
2015-09-22 00:17
Second Decision
2015-10-22 15:07
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-11-04 17:16
Articles in Press
2015-11-04 17:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-02-18 08:20
Publish the Manuscript Online
2016-02-25 19:30
ISSN 1949-8454 (online)
Open Access Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cell Biology
Manuscript Type Review
Article Title Dynamic interplay between adhesion surfaces in carcinomas: Cell-cell and cell-matrix crosstalk
Manuscript Source Invited Manuscript
All Author List Yvonne E Smith, Sri HariKrishna Vellanki and Ann M Hopkins
Funding Agency and Grant Number
Funding Agency Grant Number
Past and present funding in the senior author’s laboratory as follows - Health Research Board of Ireland HRA-POR-2014-545
Past and present funding in the senior author’s laboratory as follows - Health Research Board of Ireland HRA/2009/49
Past and present funding in the senior author’s laboratory as follows - Health Research Board of Ireland RP/2006/95 (to Hopkins AM)
Science Foundation Ireland 13/IA/1994
Science Foundation Ireland 2008/RFP/NSC1427
Science Foundation Ireland 2008/RFP/NSC1427 TIDA Feasibility 10 to Hopkins AM
Brazil Science Without Borders CAPES-13306-13-8
Beaumont Hospital Cancer Research and Development Trust
Corresponding author Ann M Hopkins, PhD, Department of Surgery, Royal College of Surgeons in Ireland, RCSI Education and Research Centre, Smurfit Building, Beaumont Hospital, Dublin 9, Ireland. annhopkins@rcsi.ie
Keywords Cell-cell; Cell-matrix; Adhesion; Cancer; Crosstalk; Pathogens; Epithelial; Barrier function; Tight junction; Cell migration; Apical junctional complex; Adherens junction; Adhesion molecules; Extracellular matrix; Tyrosine kinases; GTPases; Rho
Core Tip Deregulation of cell-cell and cell-matrix signaling makes well-established contributions to key elements of cancer initiation and progression. In this review we discuss mechanisms of crosstalk between these spatially-distinct adhesion sites in epithelial cells, with a view to understanding their therapeutic targeting in epithelial tumors (carcinomas). A particular focus is placed upon Rho GTPases and tyrosine kinases as mediators of inter-junctional crosstalk, in addition to the concept of opportunistic pathogenic infection as a paradigm for inter-junctional crosstalk. Overall, this review posits that a greater understanding of cell-cell and cell-matrix adhesion crosstalk will drive novel aspects of cancer drug discovery.
Publish Date 2016-02-25 19:30
Citation Smith YE, Vellanki SH, Hopkins AM. Dynamic interplay between adhesion surfaces in carcinomas: Cell-cell and cell-matrix crosstalk. World J Biol Chem 2016; 7(1): 64-77
Url http://www.wjgnet.com/1949-8454/full/v7/i1/64.htm
DOI http://dx.doi.org/10.4331/wjbc.v7.i1.64
Full Article (PDF) WJBC-7-64.pdf
Full Article (Word) WJBC-7-64.doc
Manuscript File 20525-Review.docx
Answering Reviewers 20525-Answering reviewers.pdf
Audio Core Tip 20525-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 20525-Conflict-of-interest statement.pdf
Copyright License Agreement 20525-Copyright assignment.pdf
Peer-review Report 20525-Peer-review(s).pdf
Scientific Misconduct Check 20525-Scientific misconduct check.pdf
Scientific Editor Work List 20525-Scientific editor work list.pdf