BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
2/25/2016 7:30:00 PM | Browse: 1662 | Download: 2250
 |
Received |
|
2015-06-09 09:17 |
|
Peer-Review Started |
|
2015-06-11 16:18 |
 |
First Decision by Editorial Office Director |
|
|
|
Return for Revision |
|
2015-08-25 14:51 |
|
Revised |
|
2015-09-22 00:17 |
|
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2015-10-22 15:07 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2015-11-04 17:16 |
|
Articles in Press |
|
2015-11-04 17:16 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2016-02-18 08:20 |
|
Publish the Manuscript Online |
|
2016-02-25 19:30 |
| ISSN |
1949-8454 (online) |
| Open Access |
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
|
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
|
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Review |
| Article Title |
Dynamic interplay between adhesion surfaces in carcinomas: Cell-cell and cell-matrix crosstalk
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Yvonne E Smith, Sri HariKrishna Vellanki and Ann M Hopkins |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Past and present funding in the senior author’s laboratory as follows - Health Research Board of Ireland |
HRA-POR-2014-545 |
| Past and present funding in the senior author’s laboratory as follows - Health Research Board of Ireland |
HRA/2009/49 |
| Past and present funding in the senior author’s laboratory as follows - Health Research Board of Ireland |
RP/2006/95 (to Hopkins AM) |
| Science Foundation Ireland |
13/IA/1994 |
| Science Foundation Ireland |
2008/RFP/NSC1427 |
| Science Foundation Ireland |
2008/RFP/NSC1427 TIDA Feasibility 10 to Hopkins AM |
| Brazil Science Without Borders |
CAPES-13306-13-8 |
| Beaumont Hospital Cancer Research and Development Trust |
|
|
| Corresponding Author |
Ann M Hopkins, PhD, Department of Surgery, Royal College of Surgeons in Ireland, RCSI Education and Research Centre, Smurfit Building, Beaumont Hospital, Dublin 9, Ireland. annhopkins@rcsi.ie
|
| Key Words |
Cell-cell; Cell-matrix; Adhesion; Cancer; Crosstalk; Pathogens; Epithelial; Barrier function; Tight junction; Cell migration; Apical junctional complex; Adherens junction; Adhesion molecules; Extracellular matrix; Tyrosine kinases; GTPases; Rho |
| Core Tip |
Deregulation of cell-cell and cell-matrix signaling makes well-established contributions to key elements of cancer initiation and progression. In this review we discuss mechanisms of crosstalk between these spatially-distinct adhesion sites in epithelial cells, with a view to understanding their therapeutic targeting in epithelial tumors (carcinomas). A particular focus is placed upon Rho GTPases and tyrosine kinases as mediators of inter-junctional crosstalk, in addition to the concept of opportunistic pathogenic infection as a paradigm for inter-junctional crosstalk. Overall, this review posits that a greater understanding of cell-cell and cell-matrix adhesion crosstalk will drive novel aspects of cancer drug discovery.
|
| Publish Date |
2016-02-25 19:30 |
| Citation |
Smith YE, Vellanki SH, Hopkins AM. Dynamic interplay between adhesion surfaces in carcinomas: Cell-cell and cell-matrix crosstalk. World J Biol Chem 2016; 7(1): 64-77 |
| URL |
http://www.wjgnet.com/1949-8454/full/v7/i1/64.htm |
| DOI |
http://dx.doi.org/10.4331/wjbc.v7.i1.64 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
