Publication Name	World Journal of Biological Chemistry
Manuscript ID	20554
Country	United States

Received	2015-06-10 08:32
Peer-Review Started	2015-06-14 19:48
To Make the First Decision	2015-08-16 14:43
Return for Revision	2015-08-25 15:23
Revised	2015-08-26 22:13
Second Decision	2015-09-28 14:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-10-13 17:59
Articles in Press	2015-10-13 17:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-03 07:24
Publish the Manuscript Online	2015-11-23 10:19

ISSN	1949-8454 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Biochemistry & Molecular Biology
Manuscript Type	Review
Article Title	Regulation of MYC gene expression by aberrant Wnt/β-catenin signaling in colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Sherri Rennoll and Gregory Yochum
Funding Agency and Grant Number	Funding Agency Grant Number Pennsylvania State University College of Medicine
Corresponding Author	Gregory Yochum, PhD, Department of Biochemistry and Molecular Biology, the Pennsylvania State University College of Medicine, Mail code H171, PO Box 850, Hershey, PA 17033-0850, United States. gsy3@psu.edu
Key Words	Wnt; β-catenin; Chromatin looping; Wnt responsive DNA element; MYC
Core Tip	In colon cancer, mutations in components of the Wnt/β-catenin signaling pathway result in inappropriate c-MYC proto-oncogene (MYC) expression. To understand colorectal carcinogenesis requires the identification of Wnt responsive DNA elements (WREs) that control MYC expression in colorectal cancer (CRC). Through efforts to characterize MYC WREs, a model has emerged where several of these WREs appear largely dispensable for intestinal homeostasis, but are instead “hijacked” by oncogenic Wnt/β-catenin signaling to drive CRC. These findings raise the intriguing possibility that these WREs may be targeted therapeutically as an alternative approach to treat individuals afflicted by CRC. In this review, we summarize the literature describing the identification of MYC WREs and discuss how those involved in colorectal carcinogenesis may be targeted to limit progression of CRC.
Publish Date	2015-11-23 10:19
Citation	Rennoll S, Yochum G. Regulation of MYC gene expression by aberrant Wnt/β-catenin signaling in colorectal cancer. World J Biol Chem 2015; 6(4): 290-300
URL	http://www.wjgnet.com/1949-8454/full/v6/i4/290.htm
DOI	http://dx.doi.org/10.4331/wjbc.v6.i4.290

Full Article (PDF)	WJBC-6-290.pdf
Full Article (Word)	WJBC-6-290.doc
Manuscript File	20554-Review.docx
Answering Reviewers	20554-Answering reviewers.pdf
Audio Core Tip	20554-Audio core tip.wav
Conflict-of-Interest Disclosure Form	20554-Conflict-of-interest statement.pdf
Copyright License Agreement	20554-Copyright assignment.pdf
Peer-review Report	20554-Peer-review(s).pdf
Scientific Misconduct Check	20554-Scientific misconduct check.pdf
Scientific Editor Work List	20554-Scientific editor work list.pdf