Publication Name	World Journal of Gastroenterology
Manuscript ID	20567
Country	Denmark

Received	2015-06-10 16:33
Peer-Review Started	2015-06-14 17:20
To Make the First Decision	2015-07-14 12:06
Return for Revision	2015-07-27 19:58
Revised	2015-08-07 02:00
Second Decision	2015-09-28 16:20
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-09-30 10:36
Articles in Press	2015-09-30 10:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-14 11:01
Publish the Manuscript Online	2015-11-03 17:31

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Systematic Reviews
Article Title	Novel understanding of ABC transporters ABCB1/MDR/P-glycoprotein, ABCC2/MRP2, and ABCG2/BCRP in colorectal pathophysiology
Manuscript Source	Invited Manuscript
All Author List	Vibeke Andersen, Katrine Svenningsen, Lina Almind Knudsen, Axel Kornerup Hansen, Uffe Holmskov, Allan Stensballe and Ulla Vogel
Funding Agency and Grant Number
Corresponding Author	Dr. Vibeke Andersen, Molecular Diagnostic and Clinical Health Research Unit, Hospital of Southern Jutland, 6200 Aabenraa, Denmark. vandersen@health.sdu.dk
Key Words	ATP-binding cassette transporters; Colorectal cancer; Intestinal; Inflammatory bowel disease; Inflammation; Adenoma-carcinoma sequence
Core Tip	Recently, human studies reported that changes in the levels of ATP-binding cassette (ABC) transporters were early events in the adenoma-carcinoma sequence leading to colorectal cancer. A link between ABCB1, high fat diet and gut microbes in relation to colitis was suggested by the animal studies. The Abcb1 KO mice might thus serve as a model in which diet/environmental factors and microbes may be controlled and investigated in relation to intestinal inflammation. Such strategy may provide insight which can be translated into preventive and treatment strategies to benefit the patients.
Publish Date	2015-11-03 17:31
Citation	Andersen V, Svenningsen K, Knudsen LA, Hansen AK, Holmskov U, Stensballe A, Vogel U. Novel understanding of ABC transporters ABCB1/MDR/P-glycoprotein, ABCC2/MRP2, and ABCG2/BCRP in colorectal pathophysiology. World J Gastroenterol 2015; 21(41): 11862-11876
URL	http://www.wjgnet.com/1007-9327/full/v21/i41/11862.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i41.11862

Full Article (PDF)	WJG-21-11862.pdf
Full Article (Word)	WJG-21-11862.doc
Manuscript File	20567-Review.docx
Answering Reviewers	20567-Answering reviewers.pdf
Audio Core Tip	20567-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20567-Conflict-of-interest statement.pdf
Copyright License Agreement	20567-Copyright assignment.pdf
Peer-review Report	20567-Peer-review(s).pdf
Scientific Misconduct Check	20567-Scientific misconduct check.pdf
Scientific Editor Work List	20567-Scientific editor work list.pdf