Publication Name	World Journal of Hepatology
Manuscript ID	20569
Country	China

Received	2015-06-11 08:59
Peer-Review Started	2015-06-15 14:40
To Make the First Decision	2015-07-27 15:52
Return for Revision	2015-08-04 13:45
Revised	2015-08-21 13:59
Second Decision	2015-09-02 15:33
Accepted by Journal Editor-in-Chief	2015-09-04 04:23
Accepted by Executive Editor-in-Chief	2015-09-08 16:03
Articles in Press	2015-09-08 16:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-09-12 17:21
Publish the Manuscript Online	2015-09-23 12:28

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Infectious Diseases
Manuscript Type	Editorial
Article Title	Innate immune recognition of hepatitis B virus
Manuscript Source	Invited Manuscript
All Author List	Hong-Yan Liu and Xiao-Yong Zhang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81301421 National Natural Science Foundation of China 81301434
Corresponding Author	Dr. Xiao-Yong Zhang, Professor, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Depart­ment of Infectious Diseases, Nanfang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou 510515, Guangdong Province, China. xiaoyzhang@smu.edu.cn
Key Words	Hepatitis B virus; Pathogen-recognition receptor; Hepatocytes; Interferon; Innate immunity
Core Tip	Hepatitis B virus (HBV) infection is prevalent worldwide as a major public health problem and the leading cause of severe liver diseases. A plethora of evidence suggests that innate immune pathways are involved in the cross-talk between HBV components and host immune cells. Many type of cells, including hepatocytes, kupffer cells and circulating monocytes, could sense and be activated by HBV infection through specific pathogen recognition receptors, resulting in the production of pro-inflammatory cytokines and interferons. Understanding of the nature of innate immunity induced by HBV will aid to characterize the immunopathogenesis of HBV infection and to further design novel immune-based therapeutic strategies for HBV infection.
Publish Date	2015-09-23 12:28
Citation	Liu HY, Zhang XY. Innate immune recognition of hepatitis B virus. World J Hepatol 2015; 7(21): 2319-2322
URL	http://www.wjgnet.com/1948-5182/full/v7/i21/2319.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i21.2319

Full Article (PDF)	WJH-7-2319.pdf
Full Article (Word)	WJH-7-2319.doc
Manuscript File	20569-Review.docx
Answering Reviewers	20569-Answering reviewers.pdf
Audio Core Tip	20569-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	20569-Conflict-of-interest statement.pdf
Copyright License Agreement	20569-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	20569-Language certificate.pdf
Peer-review Report	20569-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	20569-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	20569-Scientific misconduct check.pdf
Scientific Editor Work List	20569-Scientific editor work list.pdf