| ISSN |
1948-5182 (online) |
| Open Access |
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, General & Internal |
| Manuscript Type |
Basic Study |
| Article Title |
Role of interleukin-1 and its antagonism of hepatic stellate cell proliferation and liver fibrosis in the Abcb4-/- mouse model
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Florian P Reiter, Ralf Wimmer, Lena Wottke, Renate Artmann, Jutta M Nagel, Manuel O Carranza, Doris Mayr, Christian Rust, Peter Fickert, Michael Trauner, Alexander L Gerbes, Simon Hohenester and Gerald U Denk |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Münchener Medizinische Wochenschrift |
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| B. Braun-Stiftung |
to Reiter FP |
| Deutsche Forschungsgemeinschaft |
HO 4460/2-1(to Hohenester S) |
| Deutsche Forschungsgemeinschaft |
RU 742/6-1(to Rust C) |
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| Corresponding Author |
Florian P Reiter, MD, Department of Medicine Ⅱ, Liver Center Munich, University of Munich, Marchioninistr. 15, D-81377 Munich,
Germany. florian.reiter@med.uni-muenchen.de
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| Key Words |
Cholestasis; Primary sclerosing cholangitis; The ATP-binding cassette transporter b4; Liver fibrosis; Interleukin-1 |
| Core Tip |
Interleukin-1 (IL-1) critically participates in hepatic stellate cells (HSCs) pathophysiology and in the progression of liver injury to fibrosis. We found that fibrosis was more pronounced in female than in male ATP-binding cassette transporter b4-/- animals. This fibrosis was associated with higher IL-1β mRNA expression levels. We showed that IL-1β promoted the proliferation of murine HSCs and described an antifibrotic effect of the clinically approved IL-1 receptor antagonist Anakinra in vitro. Despite the promising antifibrotic effects in vitro, Anakinra failed to improve liver fibrosis in this preclinical primary sclerosing cholangitis model. Its potency in other models of liver injury and fibrosis remains to be determined.
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| Publish Date |
2016-03-15 11:19 |
| Citation |
Reiter FP, Wimmer R, Wottke L, Artmann R, Nagel JM, Carranza MO, Mayr D, Rust C, Fickert P, Trauner M, Gerbes AL, Hohenester S, Denk GU. Role of interleukin-1 and its antagonism of hepatic stellate cell proliferation and liver fibrosis in the Abcb4-/- mouse model. World J Hepatol 2016; 8(8): 401-410 |
| URL |
http://www.wjgnet.com/1948-5182/full/v8/i8/401.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v8.i8.401 |
