Publication Name	World Journal of Clinical Oncology
Manuscript ID	20597
Country	France

Received	2015-06-12 10:33
Peer-Review Started	2015-06-15 15:45
To Make the First Decision	2015-09-11 15:02
Return for Revision	2015-09-17 15:09
Revised	2015-10-29 00:00
Second Decision	2015-11-12 14:09
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-11-25 17:22
Articles in Press	2015-11-25 17:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-03-23 11:27
Publish the Manuscript Online	2016-04-07 11:01

ISSN	2218-4333 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Minireviews
Article Title	Is breast conservative surgery a reasonable option in multifocal or multicentric tumors?
Manuscript Source	Unsolicited Manuscript
All Author List	Gilles Houvenaeghel, Agnès Tallet, Aurélie Jalaguier-Coudray, Monique Cohen, Marie Bannier, Camille Jauffret-Fara and Eric Lambaudie
Funding Agency and Grant Number
Corresponding Author	Gilles Houvenaeghel, MD, Institut Paoli Calmettes and CRCM, Aix Marseille Université, 232 Bd de Sainte Marguerite, 13009 Marseille, France. houvenaeghelg@ipc.unicancer.fr
Key Words	Mastectomy; Breast conservative surgery; Multifocal tumors; Multicentric tumors; Radiotherapy; Local recurrence; Breast cancer; Survival
Core Tip	Multicentric and multifocal breast tumors should be identified preoperatively in order to adapt surgical treatment. They might be associated with more frequent lymph node involvement and worse prognosis but in most studies, the rates of local recurrence are low and similar to those of unifocal tumors. Breast conservative treatment is a reasonable option in selected patients (age 50-69 years, small tumors and absence of extensive ductal carcinoma in situ). Postoperative radiotherapy, and especially boost radiotherapy must be discussed and evaluated due to the risk of increased toxicity in case of double boost.
Publish Date	2016-04-07 11:01
Citation	Houvenaeghel G, Tallet A, Jalaguier-Coudray A, Cohen M, Bannier M, Jauffret-Fara C, Lambaudie E. Is breast conservative surgery a reasonable option in multifocal or multicentric tumors? World J Clin Oncol 2016; 7(2): 234-242
URL	http://www.wjgnet.com/2218-4333/full/v7/i2/234.htm
DOI	http://dx.doi.org/10.5306/wjco.v7.i2.234

Full Article (PDF)	WJCO-7-234.pdf
Full Article (Word)	WJCO-7-234.doc
Manuscript File	20597-Review.docx
Answering Reviewers	20597-Answering reviewers.pdf
Audio Core Tip	20597-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	20597-Conflict-of-interest statement.pdf
Copyright License Agreement	20597-Copyright assignment.pdf
Peer-review Report	20597-Peer-review(s).pdf
Scientific Misconduct Check	20597-Scientific misconduct check.pdf
Scientific Editor Work List	20597-Scientific editor work list.pdf