Publication Name	World Journal of Diabetes
Manuscript ID	20617
Country	India

Received	2015-06-12 15:37
Peer-Review Started	2015-06-16 16:12
To Make the First Decision	2015-07-27 15:52
Return for Revision	2015-08-04 14:10
Revised	2015-08-11 00:00
Second Decision	2015-08-27 11:29
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-09-02 10:52
Articles in Press	2015-09-02 10:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-09-06 12:30
Publish the Manuscript Online	2015-09-15 09:14

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Allergy
Manuscript Type	Editorial
Article Title	Computational pharmacokinetics and in vitro-in vivo correlation of anti-diabetic synergistic phyto-composite blend
Manuscript Source	Invited Manuscript
All Author List	Baishakhi De, Koushik Bhandari, Nishant Chakravorty, Ranjan Mukherjee, Rohit Gundamaraju, Rajeev K Singla, Prakash Katakam, Shanta K Adiki, Biswajoy Ghosh and Analava Mitra
Funding Agency and Grant Number
Corresponding Author	Analava Mitra, MBBS, PhD, School of Medical Science and Technology, B-145, IIT Campus, IIT Kharagpur 721302, India. analavamitra@gmail.com
Key Words	In silico pharmacology; Phytosynergistic; Anti-diabetic; Simulation models; Translational health research; Bio-waiver; Signaling pathways
Core Tip	The current research scenario on anti-diabetic drug development pipeline focuses on pharmacological targets influencing the molecular pathogenesis of the disease. It encompasses receptors and enzymes that will increase insulin sensitivity, intracellular insulin signaling, enhance peripheral glucose utilizations, suppress hepatic glucose production and reduce circulating trigly-cerides levels. Combination therapy has gained significance either with herbal or synthetic drugs, though “phytosynergy” awaits proper validation to give rise to new generations of “phytopharmaceuticals”. Pharmacokinetic simulation models and established in vitro-in vivo correlation that may be extrapolated to humans can serve the purpose of bio-waiver in product transition from lab bench to patient bedside.
Publish Date	2015-09-15 09:14
Citation	De B, Bhandari K, Chakravorty N, Mukherjee R, Gundamaraju R, Singla RK, Katakam P, Adiki SK, Ghosh R, Mitra A. Computational pharmacokinetics and in vitro-in vivo correlation of anti-diabetic synergistic phyto-composite blend. World J Diabetes 2015; 6(11): 1179-1185
URL	http://www.wjgnet.com/1948-9358/full/v6/i11/1179.htm
DOI	http://dx.doi.org/10.4239/wjd.v6.i11.1179

Full Article (PDF)	WJD-6-1179.pdf
Full Article (Word)	WJD-6-1179.doc
Manuscript File	20617-Review.doc
Answering Reviewers	20617-Answering reviewers.pdf
Audio Core Tip	20617-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20617-Conflict-of-interest statement.pdf
Copyright License Agreement	20617-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	20617-Language certificate.pdf
Peer-review Report	20617-Peer-review(s).pdf
Scientific Misconduct Check	20617-Scientific misconduct check.pdf
Scientific Editor Work List	20617-Scientific editor work list.pdf