Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	20621
Country	Italy

Received	2015-06-14 18:26
Peer-Review Started	2015-06-15 10:37
To Make the First Decision	2015-08-16 14:46
Return for Revision	2015-08-25 16:50
Revised	2015-09-01 22:35
Second Decision	2015-10-22 15:07
Accepted by Journal Editor-in-Chief	2015-10-23 20:13
Accepted by Company Editor-in-Chief	2015-11-04 17:17
Articles in Press	2015-11-04 17:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-10 14:24
Publish the Manuscript Online	2016-01-14 20:17

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Antitumor effects of the benzophenanthridine alkaloid sanguinarine: Evidence and perspectives
Manuscript Source	Invited Manuscript
All Author List	Roberta Gaziano, Gabriella Moroni, Cristina Buè, Martino Tony Miele, Paola Sinibaldi-Vallebona and Francesca Pica
Funding Agency and Grant Number
Corresponding Author	Francesca Pica, MD, PhD, Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Via Montpellier, 1, 00133 Rome, Italy. pica@uniroma2.it
Key Words	Sanguinarine; Cancer; Apoptosis; Cell-cycle; Chemotherapy
Core Tip	Sanguinarine is a benzophenanthridine alkaloid isolated from the root of Sanguinaria canadensis, and other poppy Fumaria species, which exibits a clear-cut anticancer potential by inducing apoptosis and/or antiproliferative effects on tumor cells. Sanguinarine also shows antiangiogenic and anti-invasive properties, as demonstrated in vitro and in vivo. In consideration of the multiple biological effects of sanguinarine, which suggest its possible use in cancer therapy, further detailed pharmacokinetic and toxicologic studies are required to assess both the efficacy and safety of the compound before proposing a possible translation into the clinic.
Publish Date	2016-01-14 20:17
Citation	Gaziano R, Moroni G, Buè C, Miele MT, Sinibaldi-Vallebona P, Pica F. Antitumor effects of the benzophenanthridine alkaloid sanguinarine: Evidence and perspectives. World J Gastrointest Oncol 2016; 8(1): 30-39
URL	http://www.wjgnet.com/1948-5204/full/v8/i1/30.htm
DOI	http://dx.doi.org/10.4251/wjgo.v8.i1.30

Full Article (PDF)	WJGO-8-30.pdf
Full Article (Word)	WJGO-8-30.doc
Manuscript File	20621-Review.doc
Answering Reviewers	20621-Answering reviewers.pdf
Audio Core Tip	20621-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20621-Conflict-of-interest statement.pdf
Copyright License Agreement	20621-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	20621-Language certificate.pdf
Peer-review Report	20621-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	20621-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	20621-Scientific misconduct check.pdf
Scientific Editor Work List	20621-Scientific editor work list.pdf